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No gods, no kings, only NOPE - or divining the future with options flows. [Part 3: Hedge Winding, Unwinding, and the NOPE]

Hello friends!
We're on the last post of this series ("A Gentle Introduction to NOPE"), where we get to use all the Big Boy Concepts (TM) we've discussed in the prior posts and put them all together. Some words before we begin:
  1. This post will be massively theoretical, in the sense that my own speculation and inferences will be largely peppered throughout the post. Are those speculations right? I think so, or I wouldn't be posting it, but they could also be incorrect.
  2. I will briefly touch on using the NOPE this slide, but I will make a secondary post with much more interesting data and trends I've observed. This is primarily for explaining what NOPE is and why it potentially works, and what it potentially measures.
My advice before reading this is to glance at my prior posts, and either read those fully or at least make sure you understand the tl;drs:
https://www.reddit.com/thecorporation/collection/27dc72ad-4e78-44cd-a788-811cd666e32a
Depending on popular demand, I will also make a last-last post called FAQ, where I'll tabulate interesting questions you guys ask me in the comments!
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So a brief recap before we begin.
Market Maker ("Mr. MM"): An individual or firm who makes money off the exchange fees and bid-ask spread for an asset, while usually trying to stay neutral about the direction the asset moves.
Delta-gamma hedging: The process Mr. MM uses to stay neutral when selling you shitty OTM options, by buying/selling shares (usually) of the underlying as the price moves.
Law of Surprise [Lily-ism]: Effectively, the expected profit of an options trade is zero for both the seller and the buyer.
Random Walk: A special case of a deeper probability probability called a martingale, which basically models stocks or similar phenomena randomly moving every step they take (for stocks, roughly every millisecond). This is one of the most popular views of how stock prices move, especially on short timescales.
Future Expected Payoff Function [Lily-ism]: This is some hidden function that every market participant has about an asset, which more or less models all the possible future probabilities/values of the assets to arrive at a "fair market price". This is a more generalized case of a pricing model like Black-Scholes, or DCF.
Counter-party: The opposite side of your trade (if you sell an option, they buy it; if you buy an option, they sell it).
Price decoherence ]Lily-ism]: A more generalized notion of IV Crush, price decoherence happens when instead of the FEPF changing gradually over time (price formation), the FEPF rapidly changes, due usually to new information being added to the system (e.g. Vermin Supreme winning the 2020 election).
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One of the most popular gambling events for option traders to play is earnings announcements, and I do owe the concept of NOPE to hypothesizing specifically about the behavior of stock prices at earnings. Much like a black hole in quantum mechanics, most conventional theories about how price should work rapidly break down briefly before, during, and after ER, and generally experienced traders tend to shy away from playing earnings, given their similar unpredictability.
Before we start: what is NOPE? NOPE is a funny backronym from Net Options Pricing Effect, which in its most basic sense, measures the impact option delta has on the underlying price, as compared to share price. When I first started investigating NOPE, I called it OPE (options pricing effect), but NOPE sounds funnier.
The formula for it is dead simple, but I also have no idea how to do LaTeX on reddit, so this is the best I have:

https://preview.redd.it/ais37icfkwt51.png?width=826&format=png&auto=webp&s=3feb6960f15a336fa678e945d93b399a8e59bb49
Since I've already encountered this, put delta in this case is the absolute value (50 delta) to represent a put. If you represent put delta as a negative (the conventional way), do not subtract it; add it.
To keep this simple for the non-mathematically minded: the NOPE today is equal to the weighted sum (weighted by volume) of the delta of every call minus the delta of every put for all options chains extending from today to infinity. Finally, we then divide that number by the # of shares traded today in the market session (ignoring pre-market and post-market, since options cannot trade during those times).
Effectively, NOPE is a rough and dirty way to approximate the impact of delta-gamma hedging as a function of share volume, with us hand-waving the following factors:
  1. To keep calculations simple, we assume that all counter-parties are hedged. This is obviously not true, especially for idiots who believe theta ganging is safe, but holds largely true especially for highly liquid tickers, or tickers will designated market makers (e.g. any ticker in the NASDAQ, for instance).
  2. We assume that all hedging takes place via shares. For SPY and other products tracking the S&P, for instance, market makers can actually hedge via futures or other options. This has the benefit for large positions of not moving the underlying price, but still makes up a fairly small amount of hedges compared to shares.

Winding and Unwinding

I briefly touched on this in a past post, but two properties of NOPE seem to apply well to EER-like behavior (aka any binary catalyst event):
  1. NOPE measures sentiment - In general, the options market is seen as better informed than share traders (e.g. insiders trade via options, because of leverage + easier to mask positions). Therefore, a heavy call/put skew is usually seen as a bullish sign, while the reverse is also true.
  2. NOPE measures system stability
I'm not going to one-sentence explain #2, because why say in one sentence what I can write 1000 words on. In short, NOPE intends to measure sensitivity of the system (the ticker) to disruption. This makes sense, when you view it in the context of delta-gamma hedging. When we assume all counter-parties are hedged, this means an absolutely massive amount of shares get sold/purchased when the underlying price moves. This is because of the following:
a) Assume I, Mr. MM sell 1000 call options for NKLA 25C 10/23 and 300 put options for NKLA 15p 10/23. I'm just going to make up deltas because it's too much effort to calculate them - 30 delta call, 20 delta put.
This implies Mr. MM needs the following to delta hedge: (1000 call options * 30 shares to buy for each) [to balance out writing calls) - (300 put options * 20 shares to sell for each) = 24,000 net shares Mr. MM needs to acquire to balance out his deltas/be fully neutral.
b) This works well when NKLA is at $20. But what about when it hits $19 (because it only can go down, just like their trucks). Thanks to gamma, now we have to recompute the deltas, because they've changed for both the calls (they went down) and for the puts (they went up).
Let's say to keep it simple that now my calls are 20 delta, and my puts are 30 delta. From the 24,000 net shares, Mr. MM has to now have:
(1000 call options * 20 shares to have for each) - (300 put options * 30 shares to sell for each) = 11,000 shares.
Therefore, with a $1 shift in price, now to hedge and be indifferent to direction, Mr. MM has to go from 24,000 shares to 11,000 shares, meaning he has to sell 13,000 shares ASAP, or take on increased risk. Now, you might be saying, "13,000 shares seems small. How would this disrupt the system?"
(This process, by the way, is called hedge unwinding)
It won't, in this example. But across thousands of MMs and millions of contracts, this can - especially in highly optioned tickers - make up a substantial fraction of the net flow of shares per day. And as we know from our desk example, the buying or selling of shares directly changes the price of the stock itself.
This, by the way, is why the NOPE formula takes the shape it does. Some astute readers might notice it looks similar to GEX, which is not a coincidence. GEX however replaces daily volume with open interest, and measures gamma over delta, which I did not find good statistical evidence to support, especially for earnings.
So, with our example above, why does NOPE measure system stability? We can assume for argument's sake that if someone buys a share of NKLA, they're fine with moderate price swings (+- $20 since it's NKLA, obviously), and in it for the long/medium haul. And in most cases this is fine - we can own stock and not worry about minor swings in price. But market makers can't* (they can, but it exposes them to risk), because of how delta works. In fact, for most institutional market makers, they have clearly defined delta limits by end of day, and even small price changes require them to rebalance their hedges.
This over the whole market adds up to a lot shares moving, just to balance out your stupid Robinhood YOLOs. While there are some tricks (dark pools, block trades) to not impact the price of the underlying, the reality is that the more options contracts there are on a ticker, the more outsized influence it will have on the ticker's price. This can technically be exactly balanced, if option put delta is equal to option call delta, but never actually ends up being the case. And unlike shares traded, the shares representing the options are more unstable, meaning they will be sold/bought in response to small price shifts. And will end up magnifying those price shifts, accordingly.

NOPE and Earnings

So we have a new shiny indicator, NOPE. What does it actually mean and do?
There's much literature going back to the 1980s that options markets do have some level of predictiveness towards earnings, which makes sense intuitively. Unlike shares markets, where you can continue to hold your share even if it dips 5%, in options you get access to expanded opportunity to make riches... and losses. An options trader betting on earnings is making a risky and therefore informed bet that he or she knows the outcome, versus a share trader who might be comfortable bagholding in the worst case scenario.
As I've mentioned largely in comments on my prior posts, earnings is a special case because, unlike popular misconceptions, stocks do not go up and down solely due to analyst expectations being meet, beat, or missed. In fact, stock prices move according to the consensus market expectation, which is a function of all the participants' FEPF on that ticker. This is why the price moves so dramatically - even if a stock beats, it might not beat enough to justify the high price tag (FSLY); even if a stock misses, it might have spectacular guidance or maybe the market just was assuming it would go bankrupt instead.
To look at the impact of NOPE and why it may play a role in post-earnings-announcement immediate price moves, let's review the following cases:
  1. Stock Meets/Exceeds Market Expectations (aka price goes up) - In the general case, we would anticipate post-ER market participants value the stock at a higher price, pushing it up rapidly. If there's a high absolute value of NOPE on said ticker, this should end up magnifying the positive move since:
a) If NOPE is high negative - This means a ton of put buying, which means a lot of those puts are now worthless (due to price decoherence). This means that to stay delta neutral, market makers need to close out their sold/shorted shares, buying them, and pushing the stock price up.
b) If NOPE is high positive - This means a ton of call buying, which means a lot of puts are now worthless (see a) but also a lot of calls are now worth more. This means that to stay delta neutral, market makers need to close out their sold/shorted shares AND also buy more shares to cover their calls, pushing the stock price up.
2) Stock Meets/Misses Market Expectations (aka price goes down) - Inversely to what I mentioned above, this should push to the stock price down, fairly immediately. If there's a high absolute value of NOPE on said ticker, this should end up magnifying the negative move since:
a) If NOPE is high negative - This means a ton of put buying, which means a lot of those puts are now worth more, and a lot of calls are now worth less/worth less (due to price decoherence). This means that to stay delta neutral, market makers need to sell/short more shares, pushing the stock price down.
b) If NOPE is high positive - This means a ton of call buying, which means a lot of calls are now worthless (see a) but also a lot of puts are now worth more. This means that to stay delta neutral, market makers need to sell even more shares to keep their calls and puts neutral, pushing the stock price down.
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Based on the above two cases, it should be a bit more clear why NOPE is a measure of sensitivity to system perturbation. While we previously discussed it in the context of magnifying directional move, the truth is it also provides a directional bias to our "random" walk. This is because given a price move in the direction predicted by NOPE, we expect it to be magnified, especially in situations of price decoherence. If a stock price goes up right after an ER report drops, even based on one participant deciding to value the stock higher, this provides a runaway reaction which boosts the stock price (due to hedging factors as well as other participants' behavior) and inures it to drops.

NOPE and NOPE_MAD

I'm going to gloss over this section because this is more statistical methods than anything interesting. In general, if you have enough data, I recommend using NOPE_MAD over NOPE. While NOPE in theory represents a "real" quantity (net option delta over net share delta), NOPE_MAD (the median absolute deviation of NOPE) does not. NOPE_MAD simply answecompare the following:
  1. How exceptional is today's NOPE versus historic baseline (30 days prior)?
  2. How do I compare two tickers' NOPEs effectively (since some tickers, like TSLA, have a baseline positive NOPE, because Elon memes)? In the initial stages, we used just a straight numerical threshold (let's say NOPE >= 20), but that quickly broke down. NOPE_MAD aims to detect anomalies, because anomalies in general give you tendies.
I might add the formula later in Mathenese, but simply put, to find NOPE_MAD you do the following:
  1. Calculate today's NOPE score (this can be done end of day or intraday, with the true value being EOD of course)
  2. Calculate the end of day NOPE scores on the ticker for the previous 30 trading days
  3. Compute the median of the previous 30 trading days' NOPEs
  4. From the median, find the 30 days' median absolute deviation (https://en.wikipedia.org/wiki/Median_absolute_deviation)
  5. Find today's deviation as compared to the MAD calculated by: [(today's NOPE) - (median NOPE of last 30 days)] / (median absolute deviation of last 30 days)
This is usually reported as sigma (σ), and has a few interesting properties:
  1. The mean of NOPE_MAD for any ticker is almost exactly 0.
  2. [Lily's Speculation's Speculation] NOPE_MAD acts like a spring, and has a tendency to reverse direction as a function of its magnitude. No proof on this yet, but exploring it!

Using the NOPE to predict ER

So the last section was a lot of words and theory, and a lot of what I'm mentioning here is empirically derived (aka I've tested it out, versus just blabbered).
In general, the following holds true:
  1. 3 sigma NOPE_MAD tends to be "the threshold": For very low NOPE_MAD magnitudes (+- 1 sigma), it's effectively just noise, and directionality prediction is low, if not non-existent. It's not exactly like 3 sigma is a play and 2.9 sigma is not a play; NOPE_MAD accuracy increases as NOPE_MAD magnitude (either positive or negative) increases.
  2. NOPE_MAD is only useful on highly optioned tickers: In general, I introduce another parameter for sifting through "candidate" ERs to play: option volume * 100/share volume. When this ends up over let's say 0.4, NOPE_MAD provides a fairly good window into predicting earnings behavior.
  3. NOPE_MAD only predicts during the after-market/pre-market session: I also have no idea if this is true, but my hunch is that next day behavior is mostly random and driven by market movement versus earnings behavior. NOPE_MAD for now only predicts direction of price movements right between the release of the ER report (AH or PM) and the ending of that market session. This is why in general I recommend playing shares, not options for ER (since you can sell during the AH/PM).
  4. NOPE_MAD only predicts direction of price movement: This isn't exactly true, but it's all I feel comfortable stating given the data I have. On observation of ~2700 data points of ER-ticker events since Mar 2019 (SPY 500), I only so far feel comfortable predicting whether stock price goes up (>0 percent difference) or down (<0 price difference). This is +1 for why I usually play with shares.
Some statistics:
#0) As a baseline/null hypothesis, after ER on the SPY500 since Mar 2019, 50-51% price movements in the AH/PM are positive (>0) and ~46-47% are negative (<0).
#1) For NOPE_MAD >= +3 sigma, roughly 68% of price movements are positive after earnings.
#2) For NOPE_MAD <= -3 sigma, roughly 29% of price movements are positive after earnings.
#3) When using a logistic model of only data including NOPE_MAD >= +3 sigma or NOPE_MAD <= -3 sigma, and option/share vol >= 0.4 (around 25% of all ERs observed), I was able to achieve 78% predictive accuracy on direction.

Caveats/Read This

Like all models, NOPE is wrong, but perhaps useful. It's also fairly new (I started working on it around early August 2020), and in fact, my initial hypothesis was exactly incorrect (I thought the opposite would happen, actually). Similarly, as commenters have pointed out, the timeline of data I'm using is fairly compressed (since Mar 2019), and trends and models do change. In fact, I've noticed significantly lower accuracy since the coronavirus recession (when I measured it in early September), but I attribute this mostly to a smaller date range, more market volatility, and honestly, dumber option traders (~65% accuracy versus nearly 80%).
My advice so far if you do play ER with the NOPE method is to use it as following:
  1. Buy/short shares approximately right when the market closes before ER. Ideally even buying it right before the earnings report drops in the AH session is not a bad idea if you can.
  2. Sell/buy to close said shares at the first sign of major weakness (e.g. if the NOPE predicted outcome is incorrect).
  3. Sell/buy to close shares even if it is correct ideally before conference call, or by the end of the after-market/pre-market session.
  4. Only play tickers with high NOPE as well as high option/share vol.
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In my next post, which may be in a few days, I'll talk about potential use cases for SPY and intraday trends, but I wanted to make sure this wasn't like 7000 words by itself.
Cheers.
- Lily
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The Challenges of Designing a Modern Skill, Part 3

Okay, Wendy’s or Walgreens or whoever, I don’t care who you are, you’re listening to the rest.

Introduction to Part 3

Welcome back one last time to “The Challenges of Designing a Modern Skill,” a series where we discuss all aspects of skill design and development. In Part 1, we talked about OSRS’s history with skills, and started the lengthy conversation on Skill Design Philosophy, including the concepts of Core, Expansion, and Integration. This latter topic consumed the entirety of Part 2 as well, which covered Rewards and Motivations, Progression, Buyables, as well as Unconstructive Arguments.
Which brings us to today, the final part of our discussion. In this Part 3, we’ll finish up Section 3 – Skill Design Philosophy, then move on to chat about the design and blog process. One last time, this discussion was intended to be a single post, but its length outgrew the post character limit twice. Therefore, it may be important to look at the previous two parts for clarity and context with certain terms. The final product, in its purest, aesthetic, and unbroken form, can be found here.

3-C – Skill Design Philosophy, Continued

3-12 - Balancing

What follows from the discussion about XP and costs, of course, is balancing: the bane of every developer. A company like Riot knows better than anyone that having too many factors to account for makes good balance impossible. Balancing new ideas appropriately is extremely challenging and requires a great respect for current content as discussed in Section 3-5 – Integration. Thankfully, in OSRS we only have three major balancing factors: Profit, XP Rate, and Intensity, and two minor factors: Risk and Leniency. These metrics must amount to some sense of balance (besides Leniency, which as we’ll see is the definition of anti-balance) in order for a piece of content to feel like it’s not breaking the system or rendering all your previous efforts meaningless. It’s also worthy to note that there is usually a skill-specific limit to the numerical values of these metrics. For example, Runecrafting will never receive a training method that grants 200k xp/hr, while for Construction that’s easily on the lower end of the scale.
A basic model works better than words to describe these factors, and therefore, being the phenomenal artist that I am, I have constructed one, which I’ve dubbed “The Guthix Scale.” But I’ll be cruel and use words anyway.
  • Profit: how much you gain from a task, or how much you lose. Gain or loss can include resources, cosmetics, specialized currencies, good old gold pieces, or anything on that line.
  • XP Rate: how fast you gain XP.
  • Intensity: how much effort (click intensity), attention (reaction intensity), and thought (planning intensity) you need to put into the activity to perform it well.
  • Risk: how likely is the loss of your revenue and/or resource investment into the activity. Note that one must be careful with risk, as players are very good at abusing systems intended to encourage higher risk levels to minimize how much they’re actually risking.
  • Leniency: a measure for how imbalanced a piece of content can be before the public and/or Jagex nerfs it. Leniency serves as a simple modulator to help comprehend when the model breaks or bends in unnatural ways, and is usually determined by how enjoyable and abusable an activity is, such that players don’t want to cause an outrage over it. For example, Slayer has a high level of Leniency; people don’t mind that some Slayer tasks grant amazing XP Rates, great Profits, have middling Intensity, and low Risk. On the other hand, Runecrafting has low levels of Leniency; despite low Risk, many Runecrafting activities demand high Intensity for poor XP Rates and middling Profits.
In the end, don’t worry about applying specific numbers during the conceptual phase of your skill design. However, when describing an activity to your reader, it’s always useful if you give approximations, such as “high intensity” or “low risk,” so that they get an idea of the activity’s design goals as well as to guide the actual development of that activity. Don’t comment on the activity’s Leniency though, as that would be pretty pretentious and isn’t for you to determine anyway.

3-13 - Skill Bloat

What do the arts of weaving, tanning, sowing, spinning, pottery, glassmaking, jewellery, engraving, carving, chiselling, carpentry, and even painting have in common? In real life, there’s only so much crossover between these arts, but in Runescape they’re all simply Crafting.
The distinction between what deserves to be its own skill or instead tagged along to a current skill is often arbitrary; this is the great challenge of skill bloat. The fundamental question for many skill concepts is: does this skill have enough depth to stand on its own? The developers of 2006 felt that there was sufficient depth in Construction to make it something separate from Crafting, even if the latter could have covered the former. While there’s often no clean cut between these skills (why does making birdhouses use Crafting instead of Construction?), it is easy to see that Construction has found its own solid niche that would’ve been much too big to act as yet another Expansion of Crafting.
On the other hand, a skill with extremely limited scope and value perhaps should be thrown under the umbrella of a larger skill. Take Firemaking: it’s often asked why it deserves to be its own skill given how limited its uses are. This is one of those ideas that probably should have just been thrown under Crafting or even Woodcutting. But again, the developers who made early Runescape did not battle with the same ideas as the modern player; they simply felt like Firemaking was a good idea for a skill. Similarly, the number of topics that the Magic skill covers is so often broken down in other games, like Morrowind’s separation between Illusion, Conjuration, Alteration, Destruction, Mysticism, Restoration, Enchant, Alchemy (closer to Herblore), and Unarmored (closer to Strength and Defense). Why does Runescape not break Magic into more skills? The answer is simple: Magic was created with a much more limited scope in Runescape, and there has not been enough content in any specific magical category to justify another skill being born. But perhaps your skill concept seeks to address this; maybe your Enchantment skill takes the enchanting aspects of Magic away, expands the idea to include current imbues and newer content, and fully fleshes the idea out such that the Magic skill alone cannot contain it. Somewhat ironically, Magic used to be separated into Good and Evil Magic skills in Runescape Classic, but that is another topic.
So instead of arguments about what could be thrown under another skill’s umbrella, perhaps we should be asking: is there enough substance to this skill concept for it to stand on its own, outside of its current skill categorization? Of course, this leads to a whole other debate about how much content is enough for a skill idea to deserve individuality, but that would get too deep into specifics and is outside the scope of this discussion.

3-14 - Skill Endgame

Runescape has always been a sandbox MMO, but the original Runescape experience was built more or less with a specific endgame in mind: killing players and monsters. Take the Runescape Classic of 2001: you had all your regular combat skills, but even every other skill had an endgame whose goal was helping combat out. Fishing, Firemaking, and Cooking would provide necessary healing. Smithing and Crafting, along with their associated Gathering skill partners, served to gear you up. Combat was the simple endgame and most mechanics existed to serve that end.
However, since those first days, the changing endgame goals of players have promoted a vast expansion of the endgame goals of new content. For example, hitting a 99 in any non-combat skill is an endgame goal in itself for many players, completely separate from that skill’s combat relationship (if any). These goals have increased to aspects like cosmetic collections, pets, maxed stats, all quests completed, all diaries completed, all music tracks unlocked, a wealthy bank, the collection log, boss killcounts, and more. Whereas skills used to have a distinct part of a system that ultimately served combat, we now have a vast variety of endgame goals that a skill can be directed towards. You can even see a growth in this perspective as new skills were released up to 2007: Thieving mainly nets you valuable (or once valuable) items which have extremely flexible uses, and Construction has a strong emphasis on cosmetics for your POH.
So when designing your new skill, contemplate what the endgame of your skill looks like. For example, if you are proposing a Gathering skill, what is the Production skill tie-in, and what is the endgame goal of that Production skill? Maybe your new skill Spelunking has an endgame in gathering rare collectibles that can be shown off in your POH. Maybe your new skill Necromancy functions like a Support skill, giving you followers that help speed along resource gathering, and letting you move faster to the endgame goal of the respective Production skill. Whatever it is, a proper, clear, and unified view of an endgame goal helps a skill feel like it serves a distinct and valuable purpose. Note that this could mean that you require multiple skills to be released simultaneously for each to feed into each other and form an appropriate endgame. In that case, go for it – don’t make it a repeat of RS3’s Divination, a Gathering skill left hanging without the appropriate Production skill partner of Invention for over 2 years.
A good example of a skill with a direct endgame is… most of them. Combat is a well-accepted endgame, and traditionally, most skills are intended to lend a hand in combat whether by supplies or gear. A skill with a poor endgame would be Hunter: Hunter is so scattered in its ultimate endgame goals, trying to touch on small aspects of everything like combat gear, weight reduction, production, niche skilling tools, and food. There’s a very poor sense of identity to Hunter’s endgame, and it doesn’t help that very few of these rewards are actually viable or interesting in the current day. Similarly, while Slayer has a strong endgame goal it is terrible in its methodology, overshadowing other Production skills in their explicit purpose. A better design for Slayer’s endgame would have been to treat it as a secondary Gathering skill, to work almost like a catalyst for other Gathering-Production skill relationships. In this mindset, Slayer is where you gather valuable monster drops, combine it with traditional Gathering resources like ores from Mining, then use a Production skill like Smithing to meld them into the powerful gear that is present today. This would have kept other Gathering and Production skills at the forefront of their specialities, in contrast to today’s situation where Slayer will give fully assembled gear that’s better than anything you could receive from the appropriate skills (barring a few items that need a Production skill to piece together).

3-15 - Alternate Goals

From a game design perspective, skills are so far reaching that it can be tempting to use them to shift major game mechanics to a more favourable position. Construction is an example of this idea in action: Construction was very intentionally designed to be a massive gold sink to help a hyperinflating economy. Everything about it takes gold out of the game, whether through using a sawmill, buying expensive supplies from stores, adding rooms, or a shameless piece of furniture costing 100m that is skinned as, well, 100m on a shameless piece of furniture.
If you’re clever about it, skills are a legitimately good opportunity for such change. Sure, the gold sink is definitely a controversial feature of Construction, but for the most part it’s organic and makes sense; fancy houses and fancy cosmetics are justifiably expensive. It is notable that the controversy over Construction’s gold sink mechanism is probably levied more against the cost of training, rather than the cost of all its wonderful aesthetics. Perhaps that should have been better accounted for in its design phase, but now it is quite set in stone.
To emphasize that previous point: making large scale changes to the game through a new skill can work, but it must feel organic and secondary to the skill’s main purpose. Some people really disliked Warding because they felt it tried too hard to fix real, underlying game issues with mechanics that didn’t thematically fit or were overshadowing the skill’s Core. While this may or may not be true, if your new skill can improve the game’s integrity without sacrificing its own identity, you could avoid this argument entirely. If your skill Regency has a Core of managing global politics, but also happens to serve as a resource sink to help your failing citizens, then you’ve created a strong Core design while simultaneously improving the profitability of Gathering skills.

3-16 - The Combat No-Touch Rule

So, let’s take a moment to examine the great benefits and rationale of RS2’s Evolution of Combat:
This space has been reserved for unintelligible squabbling.
With that over, it’s obvious that the OSRS playerbase is not a big fan of making major changes to the combat system. If there’s anything that defines the OSRS experience, it has to be the janky and abusable combat system that we love. So, in the past 7 years of OSRS, how many times have you heard someone pitch a new combat skill? Practically no one ever has; a new combat skill, no matter how miniscule, would feel obtrusive to most players, and likely would not even receive 25% of votes in a poll. This goes right back to Section 3-5 – Integration, and the importance of preserving the fundamentals of OSRS’s design.
I know that my intention with this discussion was to be as definitive about skill design as possible, and in that spirit I should be delving into the design philosophy specifically behind combat skills, but I simply don’t see the benefit of me trying, and the conversation really doesn’t interest me that much. It goes without saying that as expansive as this discussion is, it does not cover every facet of skill design, which is a limitation both of my capabilities and desire to do so.

3-17 - Aesthetics

I don’t do aesthetics well. I like them, I want them, but I do not understand them; there are others much better equipped to discuss this topic than I. Nonetheless, here we go.
Since the dawn of OSRS, debates over art style and aesthetics have raged across Gielinor. After all, the OSRS Team is filled with modern day artists while OSRS is an ancient game. What were they supposed to do? Keep making dated graphics? Make content with a modernized and easily digestible style? Something in-between?
While many players shouted for more dated graphics, they were approached by an interesting predicament: which dated graphics did they want? We had a great selection present right from the start of OSRS: 2002, 2003, 2004, 2005, 2006, and 2007. People hungry for nostalgia chose the era that they grew up in, leading to frequent requests for older models like the dragon or imp, most of which were denied by Jagex (except the old Mining rock models). But which era was OSRS supposed to follow?
Jagex elected to carve their own path, but not without heavy criticism especially closer to OSRS’s conception. However, they adapted to player requests and have since gone back and fixed many of the blatant early offenders (like the Kingdom of Kourend) and adopted a more consistent flavour, one that generally respects the art style of 2007. Even though it doesn’t always hit the mark, one has to appreciate the OSRS artists for making their best attempt and listening to feedback, and here’s to hoping that their art style examination mentioned in June 2020’s Gazette bears fruit.
But what exactly is the old school art style? There are simple systems by which most players judge it in OSRS, usually by asking questions like, “Would you believe if this existed in 2007?” More informed artists will start pointing out distinct features that permeated most content from back in the day, such as low quality textures, low poly models, low FPS animations, a “low fantasy” or grounded profile that appeals somewhat to realism, reducing cartoonish exaggerations, and keeping within the lore. Compiled with this, music and sound design help that art style come to life; it can be very hard on immersion when these don’t fit. An AGS would sound jarring if its special attack sounded like a weak dagger stab, and having to endure Country Jig while roaming Hosidius suddenly sweeps you off into a different universe.
But coming back to skill design, the art, models, and sound design tend to be some of the last features, mostly because the design phase doesn’t demand such a complete picture of a skill. However, simple concept art and models can vastly improve how a skill concept is communicated and comfort players who are concerned about maintaining that “old school feel.” This will be touched on again later in this discussion under Section 5-2 – Presentation and Beta Testing.

3-18 - Afterword

Now we’ve set down the modern standards for a new skill, but the statements that started this section bear repeating: the formula we’ve established does not automatically make a good or interesting skill, as hard as we might have tried. Once again, harken back to the First Great Irony: that we are trying to inject the modern interpretation of what defines a skill upon a game that was not necessarily built to contain it. Therefore, one could just as easily deny each of the components described above, as popular or unpopular as the act might be, and their opinion could be equally valid and all this effort meaningless. Don’t take these guidelines with such stringency as to disregard all other views.

5-0 - The OSRS Team and the Design Process

If you’ve followed me all the way here, you’re likely A) exhausted and fed up of any conversation concerning new skills, or B) excited, because you’ve just struck an incredible skill idea (or perhaps one that’s always hung around your head) that happens to tick off all the above checkboxes. But unfortunately for you B types, it’s about to get pretty grim, because we’re going to go through every aspect of skill design that’s exterior to the game itself. We’ll be touching on larger topics like democracy, presentation, player mindsets, effort, and resource consumption. It’ll induce a fantastic bout of depression, so don’t get left behind.

5-1 - Designing a Skill

Thus far, Jagex has offered three potential skills to OSRS, each of which has been denied. This gives us the advantage of understanding how the skill design process works behind the scenes and lets us examine some of the issues Jagex has faced with presenting a skill to the players.
The first problem is the “one strike and you’re out” phenomenon. Simply put, players don’t like applying much effort into reading and learning. They’ll look at a developer blog highlighting a new skill idea, and if you’re lucky they’ll even read the whole thing, but how about the second developer blog? The third? Fourth? Even I find it hard to get that far. In general, people don’t like long detail-heavy essays or blogs, which is why I can invoke the ancient proverb “Ban Emily” into this post and it’ll go (almost) completely unnoticed. No matter how many improvements you make between developer blogs, you will quickly lose players with each new iteration. Similarly, developer blogs don’t have the time to talk about skill design philosophy or meta-analyse their ideas – players would get lost far too fast. This is the Second Great Irony of skill design: the more iterations you have of a lengthy idea, the less players will keep up with you.
This was particularly prominent with Warding: Battle Wards were offered in an early developer blog but were quickly cut when Jagex realized how bad the idea was. Yet people would still cite Battle Wards as the reason they voted against Warding, despite the idea having been dropped several blogs before. Similarly, people would often comment that they hated that Warding was being polled multiple times; it felt to them like Jagex was trying to brute-force it into the game. But Warding was only ever polled once, and only after the fourth developer blog - the confusion was drawn from how many times the skill was reiterated and from the length of the public design process. Sure, there are people for whom this runs the opposite way; they keep a close eye on updates and judge a piece of content on the merits of the latest iteration, but this is much less common. You could argue that one should simply disregard the ignorant people as blind comments don't contribute to the overall discussion, but you should remember that these players are also the ones voting for the respective piece of content. You could also suggest re-educating them, which is exactly what Jagex attempts with each developer blog, and still people won’t get the memo. And when it comes to the players themselves, can the playerbase really be relied on to re-educate itself?
Overall, the Second Great irony really hurts the development process and is practically an unavoidable issue. What’s the alternative? To remove the developer-player interface that leads to valuable reiterations, or does you simply have to get the skill perfect in the first developer blog?
It’s not an optimal idea, but it could help: have a small team of “delegates” – larger names that players can trust, or player influencers – come in to review a new, unannounced skill idea under NDA. If they like it, chances are that other players will too. If they don’t, reiterate or toss out the skill before it’s public. That way, you’ve had a board of experienced players who are willing to share their opinions to the public helping to determine the meat and potatoes of the skill before it is introduced to the casual eye. Now, a more polished and well-accepted product can be presented on the first run of selling a skill to the public, resulting in less reiterations being required, and demanding less effort from the average player to be fully informed over the skill’s final design.

5-2 - Presentation and Beta Testing

So you’ve got a great idea, but how are you going to sell it to the public? Looking at how the OSRS Team has handled it throughout the years, there’s a very obvious learning curve occurring. Artisan had almost nothing but text blogs being thrown to the players, Sailing started introducing some concept art and even a trailer with terrible audio recording, and Warding had concept art, in game models, gifs, and a much fancier trailer with in-game animations. A picture or video is worth a thousand words, and often the only words that players will take out of a developer blog.
You might say that presentation is everything, and that would be more true in OSRS than most games. Most activities in OSRS are extremely basic, involve minimal thought, and are incredibly grindy. Take Fishing: you click every 20 seconds on a fishing spot that is randomly placed along a section of water, get rid of your fish, then keep clicking those fishing spots. Boiling it down further, you click several arbitrary parts of your computer screen every 20 seconds. It’s hardly considered engaging, so why do some people enjoy it? Simply put: presentation. You’re given a peaceful riverside environment to chill in, you’re collecting a bunch of pixels shaped like fish, and a number tracking your xp keeps ticking up and telling you that it matters.
Now imagine coming to the players with a radical new skill idea: Mining. You describe that Mining is where you gather ores that will feed into Smithing and help create gear for players to use. The audience ponders momentarily, but they’re not quite sure it feels right and ask for a demonstration. You show them some gameplay, but your development resources were thin and instead of rocks, you put trees as placeholders. Instead of ores in your inventory, you put logs as placeholders. Instead of a pickaxe, your character is swinging a woodcutting axe as a placeholder. Sure, the mechanics might act like mining instead of woodcutting, but how well is the skill going to sell if you haven’t presented it correctly or respected it contextually?
Again, presentation is everything. Players need to be able to see the task they are to perform, see the tools they’ll use, and see the expected outcomes; otherwise, whatever you’re trying to sell will feel bland and unoriginal. And this leads to the next level of skill presentation that has yet to be employed: Beta Worlds.
Part of getting the feel of an activity is not just watching, it but acting it out as well - you’ll never understand the thrill of skydiving unless you’ve actually been skydiving. Beta Worlds are that chance for players to act out a concept without risking the real game’s health. A successful Beta can inspire confidence in players that the skill has a solid Core and interesting Expansions, while a failed Beta will make them glad that they got to try it and be fully informed before putting the skill to a poll (although that might be a little too optimistic for rage culture). Unfortunately, Betas are not without major disadvantages, the most prominent of which we shall investigate next.

5-3 - Development Effort

If you thought that the previous section on Skill Design Philosophy was lengthy and exhausting, imagine having to know all that information and then put it into practice. Mentally designing a skill in your head can be fun, but putting all that down on paper and making it actually work together, feel fully fleshed out, and following all the modern standards that players expect is extremely heavy work, especially when it’s not guaranteed to pay off in the polls like Quest or Slayer content. That’s not even taking into account the potentially immense cost of developing a new skill should it pass a poll.
Whenever people complain that Jagex is wasting their resources trying to make that specific skill work, Jagex has been very explicit about the costs to pull together a design blog being pretty minimal. Looking at the previous blogs, Jagex is probably telling the truth. It’s all just a bunch of words, a couple art sketches, and maybe a basic in-game model or gif. Not to downplay the time it takes to write well, design good models, or generate concept art, but it’s nothing like the scale of resources that some players make it out to be. Of course, if a Beta was attempted as suggested last section, this conversation would take a completely new turn, and the level of risk to invested resources would exponentially increase. But this conversation calls to mind an important question: how much effort and resources do skills require to feel complete?
Once upon a time, you could release a skill which was more or less unfinished. Take Slayer: it was released in 2005 with a pretty barebones structure. The fundamentals were all there, but the endgame was essentially a couple cool best-in-slot weapons and that was it. Since then, OSRS has updated the skill to include a huge Reward Shop system, feature 50% more monsters to slay, and to become an extremely competitive money-maker. Skills naturally undergo development over time, but it so often comes up during the designing of an OSRS skill that it "doesn't have enough to justify its existence." This was touched on deeply in Section 3-13 – Skill Bloat, but deserves reiterating here. While people recognize that skills continually evolve, the modern standard expects a new skill, upon release, to be fully preassembled before purchase. Whereas once you could get away with releasing just a skill's Core and working on Expansions down the line, that is no longer the case. But perhaps a skill might stand a better chance now than it did last year, given that the OSRS Team has doubled in number since that time.
However, judging from the skill design phases that have previously been attempted (as we’ve yet to see a skill development phase), the heaviest cost has been paid in developer mentality and motivational loss. When a developer is passionate about an idea, they spend their every waking hour pouring their mind into how that idea is going to function, especially while they’re not at work. And then they’re obligated to take player feedback and adapt their ideas, sometimes starting from scratch, particularly over something as controversial as a skill. Even if they have tough enough skin to take the heavy criticism that comes with skill design, having to write and rewrite repeatedly over the same idea to make it “perfect” is mentally exhausting. Eventually, their motivation drains as their labour bears little fruit with the audience, and they simply want to push it to the poll and be done with it. Even once all their cards are down, there’s still no guarantee that their efforts will be rewarded, even less so when it comes to skills.
With such a high mental cost with a low rate of success, you have to ask, “Was it worth it?” And that’s why new skill proposals are far and few between. A new skill used to be exciting for the development team in the actual days of 2007, as they had the developmental freedom to do whatever they wanted, but in the modern day that is not so much the case.

5-4 - The Problems of Democracy

Ever since the conceptualization of democracy in the real world, people have been very aware of its disadvantages. And while I don’t have the talent, knowledge, or time to discuss every one of these factors, there are a few that are very relevant when it comes to the OSRS Team and the polling process.
But first we should recognize the OSRS Team’s relationship with the players. More and more, the Team acts like a government to its citizens, the players, and although this situation was intentionally instated with OSRS’s release, it’s even more prominent now. The Team decides the type of content that gets to go into a poll, and the players get their input over whether that particular piece makes it in. Similarly, players make suggestions to the Team that, in many cases, the Team hadn’t thought of themselves. This synergy is phenomenal and almost unheard of among video games, but the polling system changes the mechanics of this relationship.
Polls were introduced to the burned and scarred population of players at OSRS’s release in 2013. Many of these players had just freshly come off RS2 after a series of disastrous updates or had quit long before from other controversies. The Squeal of Fortune, the Evolution of Combat, even the original Wilderness Removal had forced numerous players out and murdered their trust in Jagex. To try and get players to recommit to Runescape, Jagex offered OSRS a polling system by which the players would determine what went into the game, where the players got to hold all the cards. They also asked the players what threshold should be required for polled items to pass, and among the odd 50% or 55% being shouted out, the vast majority of players wanted 70%, 75%, 80%, or even 85%. There was a massive population in favour of a conservative game that would mostly remain untouched, and therefore kept pure from the corruption RS2 had previously endured.
Right from the start, players started noticing holes in this system. After all, the OSRS Team was still the sole decider of what would actually be polled in the first place. Long-requested changes took forever to be polled (if ever polled at all) if the OSRS Team didn’t want to deal with that particular problem or didn’t like that idea. Similarly, the Team essentially had desk jobs with a noose kept around their neck – they could perform almost nothing without the players, their slave masters, seeing, criticizing, and tearing out every inch of developmental or visionary freedom they had. Ever hear about the controversy of Erin the duck? Take a look at the wiki or do a search through the subreddit history. It’s pretty fantastic, and a good window into the minds of the early OSRS playerbase.
But as the years have gone on, the perspective of the players has shifted. There is now a much healthier and more trusting relationship between them and the Team, much more flexibility in what the players allow the Team to handle, and a much greater tolerance and even love of change.
But the challenges of democracy haven’t just fallen away. Everyone having the right to vote is a fundamental tenet of the democratic system, but unfortunately that also means that everyone has the right to vote. For OSRS, that means that every member, whether it’s their first day in game, their ten thousandth hour played, those who have no idea about what the poll’s about, those who haven’t read a single quest (the worst group), those who RWT and bot, those who scam and lure, and every professional armchair developer like myself get to vote. In short, no one will ever be perfectly informed on every aspect of the game, or at least know when to skip when they should. Similarly, people will almost never vote in favour of making their game harder, even at the cost of game integrity, or at least not enough people would vote in such a fashion to reach a 75% majority.
These issues are well recognized. The adoption of the controversial “integrity updates” was Jagex’s solution to these problems. In this way, Jagex has become even more like a government to the players. The average citizen of a democratic country cannot and will not make major decisions that favour everyone around themselves if it comes at a personal cost. Rather, that’s one of the major roles of a government: to make decisions for changes for the common good that an individual can’t or won’t make on their own. No one’s going to willingly hand over cash to help repave a road on the opposite side of the city – that’s why taxes are a necessary evil. It’s easy to see that the players don’t always know what’s best for their game and sometimes need to rely on that parent to decide for them, even if it results in some personal loss.
But players still generally like the polls, and Jagex still appears to respect them for the most part. Being the government of the game, Jagex could very well choose to ignore them, but would risk the loss of their citizens to other lands. And there are some very strong reasons to keep them: the players still like having at least one hand on the wheel when it comes to new content or ideas. Also, it acts as a nice veto card should Jagex try to push RS3’s abusive tactics on OSRS and therefore prevent such potential damage.
But now we come to the topic of today: the introduction of a new skill. Essentially, a new skill must pass a poll in order to enter the game. While it’s easy to say, “If a skill idea is good enough, it’ll pass the threshold,” that’s not entirely true. The only skill that could really pass the 75% mark is not necessarily a well-designed skill, but rather a crowd-pleasing skill. While the two aren’t mutually exclusive, the latter is far easier to make than the former. Take Dungeoneering: if you were to poll it today as an exact replica of RS2’s version, it would likely be the highest scoring skill yet, perhaps even passing, despite every criticism that’s been previously emphasized describing why it has no respect for the current definition of “skill.” Furthermore, a crowd-pleasing skill can easily fall prey to deindividualization of vision and result in a bland “studio skill” (in the same vein as a “studio film”), one that feels manufactured by a board of soulless machines rather than a director’s unique creation. This draws straight back to the afore-mentioned issues with democracy: that people A) don’t always understand what they’re voting for or against, and B) people will never vote for something that makes their game tougher or results in no benefit to oneself. Again, these were not issues in the old days of RS2, but are the problems we face with our modern standards and decision making systems.
The reality that must be faced is that the polling system is not an engine of creation nor is it a means of constructive feedback – it’s a system of judgement, binary and oversimplified in its methodology. It’s easy to interact with and requires no more than 10 seconds of a player’s time, a mere mindless moment, to decide the fate of an idea made by an individual or team, regardless of their deep or shallow knowledge of game mechanics, strong or weak vision of design philosophy, great or terrible understanding of the game’s history, and their awareness of blindness towards the modern community. It’s a system which disproportionately boils down the quality of discussion that is necessitated by a skill, which gives it the same significance as the question “Should we allow players to recolour the Rocky pet by feeding it berries?” with the only available answers being a dualistic “This idea is perfect and should be implemented exactly as outlined” or “This idea is terrible and should never be spoken of again.”
So what do you do? Let Jagex throw in whatever they want? Reduce the threshold, or reduce it just for skills? Make a poll that lists a bunch of skills and forces the players to choose one of them to enter the game? Simply poll the question, “Should we have a new skill?” then let Jagex decide what it is? Put more options on the scale of “yes” to “no” and weigh each appropriately? All these options sound distasteful because there are obvious weaknesses to each. But that is the Third Great Irony we face: an immense desire for a new skill, but no realistic means to ever get one.

6-0 - Conclusion

I can only imagine that if you’ve truly read everything up to this point, it’s taken you through quite the rollercoaster. We’ve walked through the history of OSRS skill attempts, unconstructive arguments, various aspects of modern skill design philosophy, and the OSRS Team and skill design process. When you take it all together, it’s easy to get overwhelmed by all the thought that needs to go into a modern skill and all the issues that might prevent its success. Complexity, naming conventions, categorizations, integration, rewards and motivations, bankstanding and buyables, the difficulties of skill bloat, balancing, and skill endgames, aesthetics, the design process, public presentation, development effort, democracy and polling - these are the challenges of designing and introducing modern skills. To have to cope with it all is draining and maybe even impossible, and therefore it begs the question: is trying to get a new skill even worth it?
Maybe.
Thanks for reading.
Tl;dr: Designing a modern skill requires acknowledging the vast history of Runescape, understanding why players make certain criticisms and what exactly they’re saying in terms of game mechanics, before finally developing solutions. Only then can you subject your ideas to a polling system that is built to oversimplify them.
submitted by ScreteMonge to 2007scape [link] [comments]

A trans person's measured take on the trans sports issue

So first of all this post was inspired by GGExMachina's brief statement on the issue:
For example, it is objectively the case that biological men have a physical advantage over women. Yet if someone points this out and suggests that transgender people shouldn’t be allowed to fight in women’s UFC, or women’s soccer or weightlifting competitions or whatever, suddenly you’re some kind of evil monster. Rather than saying that of course trans people shouldn’t be bullied and that we could perhaps have a trans olympics (like the Paralympics and Special Olympics), we are expected to lie.
I've found that this position is incredibly popular among liberals/left-leaning people, especially here on reddit. It seems like, once or twice a month, like clockwork, a thread stating more or less the same thing on /unpopularopinion or /offmychest will get thousands of upvotes. And while I completely understand the thought process that leads otherwise left-leaning people to come to such conclusions, I feel like the issue has been, broadly speaking, dishonestly presented to the general public by a mixture of bad-faith actors and people who have succumbed to the moral panic. And, as I've seen, there are plenty of people in this subreddit and elsewhere who are itching to be as supportive as they possibly can to the trans community but find themselves becoming very disillusioned by this particular issue. By making this post I hope to present a more nuanced take on the issue, not only in regards to my personal beliefs on what kinds of policies are best to preserve fairness in women's sports but also in regards to shining a light on how this issue is often times dishonestly presented in an attempt to impede the progression of pro-trans sentiments in the cultural zeitgeist.

Sex & Gender

The word "transgender" is an umbrella term that refers to people whose gender identities differ from those typically associated with the sex they were assigned at birth. According to the 2015 U.S. Transgender Survey, the approximate composition of "the trans community" in the United States is 29% Transgender men (Female-to-Male), 33% Transgender women (Male-to-Female), and 35% non-binary. (The remaining 3% were survey respondents who self-identified as "crossdressers", who were still included in the survey on the grounds of being gender non-conforming)
While non-binary people, as a group, are probably deserving of their own separate post. the focus of this post will be on trans men and trans women. I will also be primarily focusing on transgender people who pursue medical transition with Hormone-Replacement-Therapy, as they are most relevant to the issue of sports. (Mind that while the majority of binary trans people fit into this camp, there is a sizable minority of trans people who do not feel the need to medically transition.)
What do trans people believe about Gender?
The views of transgender people in regards to Gender are actually pretty varied, although the most prominent positions that I've personally seen are best summed up into two different camps:
  1. The "Trans-Medical" camp
Transgender people who fall into this camp usually consider Gender Dysphoria to be the defining factor of what makes somebody trans. The best way I can describe this camp is that they sort of view being transgender akin to being intersex. Only whereas an intersex person would be born with a disorder that affects the body, a trans person is born with a disorder that affects the brain. Trans people in this camp often times put an emphasis on a clinical course for treatment. For example, a person goes to a psychologist, gets diagnosed with gender dysphoria, starts hormone replacement therapy, pursues surgery, then emerges from this process of either cured of the gender dysphoria or, at the very least, treated to the fullest extent of medical intervention. This position is more or less the original position held by trans activists, back in the day when the word "transsexual" was used instead of "transgender". Though many younger trans people, notably YouTuber Blaire White, also hold this position. Under this position, sex and gender are still quite intertwined, but a trans man can still be considered a man, and a trans woman a woman, under the belief that sex/gender doesn't just refer to chromosomal sex and reproductive organs, but also to neurobiology, genitalia, and secondary sex characteristics. So someone who is transgender, according to this view, is born with the physical characteristics of one sex/gender but the neurobiology of another, and will change their physical characteristics, to the fullest extent medically possible, to match the neurobiology and therefore cure the individual of gender dysphoria.
Critics of this position argue that this mentality is problematic due to being inherently exclusive to transgender people who do not pursue medical transition, whom are often times deemed as "transtrenders" by people within this camp. Many people find it additionally problematic because it is also inherently exclusive to poorer trans people, particularly those in developing nations, who may not have access to trans-related medical care. Note that there are plenty of trans people who *do* have access to medical transition, but nevertheless feel as if the trans community shouldn't gatekeep people who cannot afford or do not desire medical transition, thus believing in the latter camp.
  1. The "Gender Identity" camp
I feel like this camp is the one most popularly criticized by people on the right, but is also probably the most mainstream. It is the viewpoint held by many more left-wing trans people, (Note that in the aforementioned 2015 survey, only 1% of trans respondents voted Republican, so trans people are largely a pretty left-wing group, therefore it makes sense that this position would be the most mainstream) but also notably held by American Psychological Association, the American Psychiatric Association, GLAAD, and other mainstream health organizations and activist groups.
While people in this camp still acknowledge that medical transition to treat gender dysphoria can still be a very important aspect of the transgender experience, it's believed that the *defining* experience is simply having a gender identity different from the one they were assigned at birth. "Gender identity" simply being the internal, personal sense of being a man, a woman, or outside the gender binary.
Many people in this camp, though, still often maintain that gender identity is (at least partially) neurobiological, but differ from the first camp in regards to acknowledging that the issue is less black & white than an individual simply having a "male brain" or a "female brain", but rather that the neurological characteristics associated with gender exist on more of a spectrum, thus leaving the door open to gender non-conforming people who do not identify as trans, as well as to non-binary people. This is where the "gender is a spectrum" phrase comes from.
"52 genders" is a popular right-wing meme that makes fun of this viewpoint, however it is important to note that many trans and non-binary people disagree with the idea of quantifying gender identity to such an absurd amount of individual genders, rather more simply maintaining that there are men, women, and a small portion of people in-between, with a few words such as "agender" or "genderqueer" being used to describe specific identities/presentations within this category.
It's also noteworthy that not all people in this camp believe that neurobiology is the be-all-end-all of gender identity, as many believe that the performativity of gender also plays an integral role in one's identity. (That gender identity is a mixture of neurobiology and performativity is a position held by YouTuber Contrapoints)
Trans people and biological sex
So while the aforementioned "Gender Identity" viewpoint has become quite popularized among liberals and leftists, I have noticed a certain rhetorical mentality/assumption become prevalent alongside it, especially among cisgender people who consider themselves trans-allies:
"Sex and Gender are different. A trans woman is a woman who is biologically male. A trans man is a man who is biologically female"
When "Sex" is defined by someone's chromosomes, or the sex organs they were born with, this is correct. However, there is a pretty good reason why the trans community tends to prefer terms like "Assigned Male at Birth" rather than "Biologically Male". This is done not only for the inclusion of people who are both intersex and transgender (For example, someone can be born intersex but assigned male based on the existence of a penis or micropenis), but also due to the aforementioned viewpoint on divergent neurobiology being the cause for gender dysphoria. Those reasons are why the word "Assigned" is used. But the reason why it's "Assigned Male/Female At Birth" instead of just "Assigned Male/Female" is because among the trans community there exists an understanding of the mutability of sexually dimorphic biology that the general population is often ignorant to. For example, often times people (especially older folks) don't even know of the existence of Hormone Replacement Therapy, and simply assume that trans people get a single "sex change operation" that, (for a trans woman) would just entail the removal of the penis and getting breast implants. Therefore they imagine the process to be "medically sculpting a male to look female" instead of a more natural biological process of switching the endocrine system form male to female or vice versa and letting the body change over the course of multiple years. It doesn't help that, for a lot of older trans people (namely Caitlyn Jenner, who is probably the most high profile trans person sadly), the body can be a lot more resistant to change even with hormones so they *do* need to rely on plastic surgery a lot more to get obvious results)
So what sexually dimorphic bodily characteristics can one expect to change from Hormone Replacement Therapy?
(Note that there is a surprising lack of studies done on some of the more intricate changes that HRT can, so I've put a "*" next to the changes that are anecdotal, but still commonly and universally observed enough among trans people [including myself for the MTF stuff] to consider factual. I've also put a "✝" next to the changes that only occur when people transition before or during puberty)
Male to Female:
Female to Male:
For the sake of visual representation, here are a couple of images from /transtimelines to demonstrate these changes in adult transitioners (I've specifically chosen athletic individuals to best demonstrate muscular changes)
https://preview.redd.it/ntw333p9sbty.jpg?width=640&crop=smart&auto=webp&s=5fe779757dfc4a5dc56566ff648d337c59fbe5cb
https://www.reddit.com/transtimelines/comments/dpca0f/3_years_on_vitamin_t/
Additionally, here's a picture of celebrity Kim Petras who transitioned before male puberty, in case you were wondering what "female pubescent skeletal development" looks like in a trans woman:
https://cdn2.thelineofbestfit.com/images/made/images/remote/https_cdn2.thelineofbestfit.com/portraits/kim_petras_burakcingi01_1107_1661_90.jpg

How does this relate to sports?

Often times, when the whole "transgender people in sports" discussion arises, a logical error is made when *all* transgender people are assumed to be "biologically" their birth sex. For example, when talking about trans women participating in female sports, these instances will be referred to as cases of "Biological males competing against females".
As mentioned before, calling a trans woman "biologically male" strictly in regards to chromosomes or sex organs at birth would be correct. However, not only can it be considered derogatory (the word "male" is colloquially a shorthand for "man", after all), but there are many instances where calling a post-HRT transgender person "biologically [sex assigned at birth]" is downright misleading.
For example, hospitals have, given transgender patients improper or erroneous medical care by assuming treatment based on birth sex where treatment based on their current endocrinological sex would have been more adequate.
Acute Clinical Care of Transgender Patients: A Review
Conclusions and relevance: Clinicians should learn how to engage with transgender patients, appreciate that unique anatomy or the use of gender-affirming hormones may affect the prevalence of certain disease (eg, cardiovascular disease, venous thromboembolism, and osteoporosis), and be prepared to manage specific issues, including those related to hormone therapy. Health care facilities should work toward providing inclusive systems of care that correctly identify and integrate information about transgender patients into the electronic health record, account for the unique needs of these patients within the facility, and through education and policy create a welcoming environment for their care.
Some hosptials have taken to labeling the biological sex of transgender patients as "MTF" (for post-HRT trans women) and "FTM" (for post-HRT trans men), which is a much more medically useful identifier compared to their sex assigned at birth.
In regards to the sports discussion, I've seen *multiple threads* where redditors have backed up their opinions on the subject of trans people in sports with studies demonstrating that cis men are, on average, more athletically capable than cis women. Which I personally find to be a pathetic misunderstanding of the entire issue.
Because we're not supposed to be comparing the athletic capabilities of natal males to natal females, here. We're supposed to comparing the athletic capabilities of *post-HRT male-to-females* to natal females. And, if we're going to really have a fact-based discussion on the matter, we need to have separate categories for pre-pubescent and post-pubescent transitioners. Since, as mentioned earlier, the former will likely have different skeletal characteristics compared to the latter.
The current International Olympic Committee (IOC) model for trans participation, and criticisms of said model
(I quoted the specific guidelines from the International Cycling Union, but similar guidelines exist for all Olympic sports)
Elite Competition
At elite competition levels, members may have the opportunity to represent the United States and participate in international competition. They may therefore be subject to the policies and regulations of the International Cycling Union (UCI) and International Olympic Committee (IOC). USA Cycling therefore follows the IOC guidelines on transgender athletes at these elite competition levels. For purposes of this policy, international competition means competition sanctioned by the UCI or competition taking place outside the United States in which USA Cycling’s competition rules do not apply.
The IOC revised its guidelines on transgender athlete participation in 2015, to focus on hormone levels and medical monitoring. The main points of the guidelines are:
Those who transition from female to male are eligible to compete in the male category without restriction. It is the responsibility of athletes to be aware of current WADA/USADA policies and file for appropriate therapeutic use exemptions.
Those who transition from male to female are eligible to compete in the female category under the following conditions:
The athlete has declared that her gender identity is female. The declaration cannot be changed, for sporting purposes, for a minimum of four years.
The athlete must demonstrate that her total testosterone level in serum has been below 10 nmol/L for at least 12 months prior to her first competition (with the requirement for any longer period to be based on a confidential case-by-case evaluation, considering whether or not 12 months is a sufficient length of time to minimize any advantage in women’s competition).
The athlete's total testosterone level in serum must remain below 10 nmol/L throughout the period of desired eligibility to compete in the female category.
Compliance with these conditions may be monitored by random or for-cause testing. In the event of non-compliance, the athlete’s eligibility for female competition will be suspended for 12 months.
Valid criticisms of the IOC model are usually based on the fact that, even though hormone replacement therapy provokes changes to muscle mass, it does *not* shrink the size of someone's skeleton or cardiovascular system. Therefore an adult-transitioned trans woman could, even after losing all levels of male-typical muscle mass, still have an advantage in certain sports if she had an excessively large skeletal frame, and was participating in a sport where such a thing would be advantageous.
Additionally, the guidelines only require that athletes be able to demonstrate having had female hormone levels for 12-24 months, which isn't necessarily long enough to completely lose musculature gained from training on testosterone (anecdotally it can take 2-4 years to completely lose male-typical muscle mass) So the IOC guidelines don't have any safeguard against, for example, a trans woman training with testosterone as the dominant hormone in her body, and then taking hormones for the bare minimum time period and still having some of the advantage left.
Note that, while lower level sports have had (to the glee of right-wing publications sensationalizing the issue) instances of this exact thing happening, in the 16 years since these IOC guidelines were established, not a single transgender individual has won an Olympic medal
Also note that none of the above criticisms of the IOC policy would apply in regards to the participation of pre-pubescent-transitioned trans women. After all, male-pubescent bone structure and cardiovascular size, and male-typical muscle levels, can't possibly exist if you never went through male puberty to begin with.
What could better guidelines entail, to best preserve fairness in female sports while avoiding succumbing to anti-trans moral panic?
In my personal opinion, sports leagues should pick one of the three above options depending on what best fits the nature of the sport and the eliteness of the competition. For example, extremely competitive contact sports might be better off going with the first option, but an aerobic sport such as marathon running would probably be fine with the third option.

How this issue has been misrepresented by The Right

I'll use Joe Rogan as an example of this last thing:
She calls herself a woman but... I tend to disagree. And, uh, she, um... she used to be a man but now she has had, she's a transgender which is (the) official term that means you've gone through it, right? And she wants to be able to fight women in MMA. I say no f***ing way.
I say if you had a dick at one point in time, you also have all the bone structure that comes with having a dick. You have bigger hands, you have bigger shoulder joints. You're a f***ing man. That's a man, OK? You can't have... that's... I don't care if you don't have a dick any more...
If you want to be a woman in the bedroom and you know you want to play house and all of that other s*** and you feel like you have, your body is really a woman's body trapped inside a man's frame and so you got a operation, that's all good in the hood. But you can't fight chicks. Get the f*** out of here. You're out of your mind. You need to fight men, you know? Period. You need to fight men your size because you're a man. You're a man without a dick.
I'm not trying to discriminate against women in any way, shape, or form and I'm a big supporter of women's fighting. I loved watching that Ronda Rousey/Liz Carmouche fight. But those are actual women. Those are actual women. And as strong as Ronda Rousey looks, she's still looks to me like a pretty girl. She's a beautiful girl who happens to be strong. She's a girl! [Fallon Fox] is not a girl, OK? This is a [transgender] woman. It's a totally different specification.
Calling a trans woman a "man", and equating transitioning to merely removal of the dick, and equating trans women's experiences as women as "playing house" and "being a woman in the bedroom". These things are obviously pretty transphobic, and if Rogan had said these things about just any random trans woman his statements would have likely been more widely seen in that light. But when it's someone having an unfair advantage in sports, and the audience is supposed to be angry with you, it's much more socially acceptable thing to say such things. But the problem is, when you say these kinds of things about one trans woman, you're essentially saying those derogatory things about all trans women by extension. It's the equivalent of using an article about a black home invader who murdered a family as an excuse to use a racial slur.
Now, I'm not saying that Rogan necessarily did this on purpose, in fact I'm more inclined to believe that it was done moreso due to ignorance rather than having an actual ideological agenda. But since then, many right wing ideologues who do have an ideological agenda have used this issue as an excuse to voice their opinions on trans people while appearing to be less bigoted. Ie. "I'm not trying to be a bigot or anything and I accept people's rights to live their lives as they see fit, but we NEED to keep men out of women's sports", as a sly way to call trans women "men".
Additionally, doing this allows them to slip in untrue statements about the biology of trans women. I mean, first of all in regards to the statement "You have bigger hands, you have bigger shoulder joints", obviously even in regards to post-pubescent transitioners, not every trans woman is going to have bigger hands and shoulder joints than every cis woman (My hands are actually smaller than my aunt's!). It's just that people who go through male puberty on average tend to have bigger hands and shoulder joints compared to people who go through female puberty. But over-exaggerating the breadth of sexual dimorphism, as if males and females are entirely different species to each-other, helps to paint the idea of transitioning in a more nonsensical light.
I hope this thread has presented this issue in a better light for anyone reading it. Let me know if you have any thoughts/criticisms of my stances or the ways I went about this issue.
submitted by Rosa_Rojacr to samharris [link] [comments]

[The Scuu Paradox] - Chapter 18

At the Beginning
Previously on The Scuu Paradox…
  The smell of burning wood was all I could focus on. The fires had long died out, making it difficult to see in the darkness; despite all other modifications, Kridib’s eyes weren’t able to see overly well in the dark. Every five minutes, Radiance would send an infrared scan of the colony to help him and his team with their advancement. Despite all that help and the four missile strikes, progress was minimal. Of the forty-seven people sent to the planet, eleven had been killed and five more severely wounded, rendering them useless in battle. From what I could see, Rigel’s forces had clustered in specific points of the colony, giving up the rest: a sensible strategy that had allowed them to ambush three of our teams while suffering negligible losses themselves. As things stood, the enemy forces had positioned themselves in two areas of the colony. Both spots encircled a specific building—mine and the captain’s locations—making further missile strikes impossible.
  Update? Kridib asked me through the mind link.
  Nothing, I replied. Rigel had left shortly after our last chat, taking the third-contact rods with him. Since then, I had remained safely isolated in the room and completely alone. Half of them have probably gone to sleep.
  Tell me if anything changes. Kribib looked up. A dozen sats were visible in the night sky. We’ll be making another go soon.
  I don’t think that’s a good idea.
  So far, Kridib had made four attempts to reach me, all of them unsuccessful. His approach, though chaotic at best, had managed to keep him alive. There had been a close call during which his left arm had been grazed by a bullet, though that time the man hadn’t frozen.
  Everyone has to sleep, Kridib said, heading back into one of the buildings that had been transformed into a ground base of operations. I’ll go first.
  Must I wake you? I asked.
  No. With that, the link was severed.
  To a degree, I was thankful, though not too much. Forcing whatever strength I had, I moved my head to look around the room as much as I was able. Nothing had changed in the last four hours, but at least it let me do something. The last time I felt remotely similar was when I’d had my sensor systems knocked out, though even then I was able to use my shuttle AIs to paint me a picture. Here, I was completely helpless and, to a vast degree, blind.
  “Do I get any water?” I asked as loudly as my lungs would let me.
  There was no reason to expect an answer. Even if anyone was awake on the lower floors, they would be on lookout duty. Saying it out loud, though, made me feel better for some reason. To my surprise, the door to the room opened.
  “Thought you were above those things.” Rigel walked in slowly. Even with my lack of focus, I could see that he had changed clothes. The colours were dark enough to be considered a uniform, although I couldn’t make out any other details. “You can’t swallow, remember?”
  “My mouth feels dry,” I explained.
  “Too bad.” Despite my poor vision, I could hear him smile as he said that.
  Walking slowly, he made his way to the stool near me and sat down. From this distance, I could see him taking something from his front pocket. In the dim light, it was impossible to tell what exactly.
  “Still having problems focusing?” Rigel asked.
  “Yes.” There was no point in lying.
  “Pity. Agora works well on organic tissue. Not on techno-mongrels,” he added with a laugh. “If you weren’t one, you’d be dead. There’s a win for you.”
  And you’re not making any sense, I thought.
  “Nice murder troops you got out there. Quick and efficient. A few years ago, the locals would’ve had fun pulling their wings off. Time leaves its mark.” Rigel flicked the object. It let out a peculiar metallic sound. “No action, no combat sims, just the local pests that roam the planet. Those were brought here too, did you know?”
  “I heard about it.”
  “Another brilliant idea from the bureaucracy. Create a full ecosystem. Plants, critters, predators... all must be present and carefully maintained. We tried killing them off once. Those were the days. Three colonies setting out, killing everything in sight until the orbital station stopped sending food.” There was a slight pause. “And you know the best part?” Rigel leaned towards me. “None of that happened.”
  If I could have pulled back, I would have. There was no way of knowing if these were insane rantings or if he was referring to a dark op coverup. Considering he was from the Salvage Authorities, either was possible, and both options were equally undesirable.
  “I went through your data, Elcy.” Rigel rubbed his hands. “You know things you shouldn’t.”
  “Because of my past, I’ve been placed on special assignments,” I said. Technically it was true, though we both knew it didn’t explain away the inconsistencies.
  “You knew about the third-contact artifacts before. You’ve operated them before.” He moved his hand closer to my face. I felt a cold metallic surface touch my cheek. “You’re searching for something. Something that you’re not supposed to find.” He moved the object away from my face. “Here’s my offer. You answer some of my questions, and I’ll answer some of yours.”
  “That’s one way to get court-martialed.” Not to mention there was no guarantee my self-destruct chip wouldn’t go off at any point.
  “Please don’t give me the line that the fleet is going through all that trouble just to rescue you. If you were that valuable, you’d never have been sent to this hell in the first place.” Rigel stood up. “What are the odds of the fleet extracting you in one piece? Two percent?”
  “Point-seven-three-nine,” I corrected. Frankly, I was surprised they were going through all the trouble. “Give or take.”
  “Less than one percent,” Rigel snorted. “It’s your call. You have three hours to make it. Before I leave you, here’s a freebie. This planet, it isn’t some randomly colonized world in ‘unexplored space.’ We’re in the buffer zone—the border between the Scuu and human space. Think about that.” He made his way to the door. Reaching it, he stopped and turned around. “Oh, and we’re constantly being monitored.”
 
  Gamma-Ligata, Cassandrian Front—615.11 A.E. (Age of Expansion)
    The third wave of shuttles approached my forward left hangar one by one. The instant they came within three hundred meters, I was handed over direct control of the AIs. As with the previous batches, the first thing I did was to have a set of isolated subroutines flash the memory and purge the entire operating system. That done, I sent out a mini-sat to latch onto and assume control of the shuttles. It was a slow and tedious process, but necessary considering the circumstances.
  “How are things?” Wilco asked from the bridge. Augustus had gathered most of his officers to a private meeting in his quarters, leaving Wilco in command. This wasn’t the first time it had happened, but each time it did, it felt strange.
  “Everything’s going as planned,” I said, as the first shuttle went under my control.
  A quick internal scan revealed that there were sixty-two people aboard, all cuffed and tagged. All of them were tagged as infected, and, to my surprise, none of them were sedated. The instructions were to take them in and monitor their actions at all times, and only to engage if they threatened the ship. Normally, I’d be confident that Augustus knew what was going on. With everything we’d gone through since I’d joined the front, I didn’t think there was anything in the galaxy that could surprise him. I was wrong.
  Finishing my internal check of the shuttle, I directed it to the outer hangar doors and had it dock. The passengers—all of their identities classified—waited till I covered the walls with disembark notifications, then stood up and quietly proceeded to get off, in orderly fashion. I could tell by Wilco’s expression that he found it unnerving.
  “A thousand and eighty-two passengers on board,” I said on the bridge and in the captain’s quarters. The moment the last person set foot in the hangar, I would eject the shuttle from my hangar-bay, self-destruct it, and proceed with the next.
  Delegating the task to my isolated subroutines, I reviewed the instructions I had received. The proper ident protocols and authorisations had been used, ensuring that I would do as instructed without asking questions. An emergency transmission from an unidentifiable ship had led me here. I knew nothing about the ship’s name or specifics, and I wasn’t allowed to get close enough to get a visual. The only things I was allowed to see were its shuttles and mass. Everything else was open to interpretation.
  “Have any of them said anything?” Wilco asked.
  “No.” I displayed images of the hangar bay and the corresponding corridors surrounding it. As part of my instructions, the entire section was sealed off and quarantined. “They’re eating.” They also appeared to be healthy, although the instructions stressed no one was to come into contact with them under any circumstances. “I’ve received no indication of how long we’re to keep them. Did the captain get an indication?”
  “No,” Wilco said in his usual somber voice. “Is everything sealed off?”
  “Yes.” I rechecked. “No way in or out without captain’s approval.”
  “Set a buffer zone.” The man went on. “No one goes in or out without my permission.”
  “If you say so.” It wasn’t difficult. The area in question had been made empty to accommodate the quarantined arrivals, though it seemed a bit too much. “Want me to put sentinels?”
  “No. We don’t have to hurt anyone, just hold them.” He slinked down in his chair. “They’re the Med boys’ toys. We don’t get to play with them.”
  Med boys… Only Wilco referred to the Medical Core in such fashion. As most organisations, they were part of the fleet, yet their specific area of expertise gave them as much authority as the Salvage Authorities and the BICEFI combined. As a ship, I knew fairly little about them: they had the power to impose quarantines and cordon off entire planets if they wished. They were also the only organisation with the power to hold an active captain in check. Possibly, that was the reason Augustus didn’t get along with any of his medical officers. According to the public files, the Med Core had created the inner-body nanites and were instrumental in getting humans into space. There were also whispers that they were involved in creating the first ship-cores, although I found that unlikely. Even so, they had more authority than anyone aboard. Even on the front, we had no option but to obey.
  “It won’t be practical heading into war with them,” I said as the second shuttle entered the hangar bay.
  “Not our call. We’re to hold them until a Med ship picks them up,” Wilco sighed. “And monitor everything they do.”
  “How is that different from anyone else aboard?” I ventured a chuckle.
  “You don’t need to know,” the lieutenant said darkly.
  Another thing about Wilco was that he had the uncanny ability to make any topic of conversation dark. I ran a few simulations testing various responses, then decided not to respond further. In the best-case scenario, there was a twenty-seven percent chance he found my reaction funny.
  “Elcy.” Augustus granted me sensor access to the captain’s quarters. “What’s the ETA on the cattle?”
  “The passengers will be all aboard in seven minutes, captain.” A decade of attempts to mellow his behaviour had brought me no results. “Five, if you need me off in a rush.”
  “Get it done in five,” he barked. “We’ve got new orders. We’re joining a purge fleet. Go on yellow. Get the grunts prepped.”
  “Aye, sir.” I issued the order to everyone aboard. Seconds later, ground troop officers and sergeants were shouting their troops into order. “What about the passengers, sir? Won’t combat expose them to unnecessary danger?”
  “There’s no unnecessary danger,” Augustus barked again. The rest of the command staff had already started leaving the room. Their expressions ranged from mild annoyance to disapproval. Whatever discussions had taken place, they must have been unpleasant and one-sided. “Monitor them at all times and don’t interact until I say so.”
  “Understood.”
  It sounded like another escort mission, and I didn’t like escort missions. Normally, it would just be troop detachments or—if we were very unlucky—some mid-level bureaucrat or admiral’s aid sent to do a front-line inspection. Transporting quarantined personnel wasn’t in my usual purview, although if it had been, I’d never know.
  “What’s the course of treatment they must undergo?” I asked.
  “No treatment,” Augustus grumbled. “That’s for the Meds to figure out.”
  “All passengers are tagged as infected. Regulations require we provide immediate medical attention.” I felt my words sound hollow. If Augustus had the authority to provide such, he would have told me already. The only thing I was left was to go through the motions, expecting to receive the obvious denial.
  “Just monitor them, Elcy! That’s what we’ve been told. And whatever happens, don’t interfere.”
 
  Just monitor them.
  I had spent three months and thirty-nine hours monitoring the passengers onboard. Through battles and repairs, every single action had been carefully observed, recorded, and stored on external data storage. For the most part, nothing happened. The people would live boring, perfectly organised lives, almost as if they knew they were being watched. There were no scuffles, few arguments, and only one incident resulting in injuries when a Cassandrian fighter managed to slip through my external defences and fire a salvo at the hangar bay. Their health condition also seemed no different than when they had come aboard. I had dedicated a dozen subroutines to collect any potential symptoms in an effort to determine the type of disease they had, but had come to no conclusion. Then, one day, they were all gone. I had no memory of the Medical ship that had taken them, or where that had happened. The only thing I was certain about was the time—precisely two thousand, one hundred and ninety-nine hours since the last of them had come aboard. Everything else remained restricted.
  Looks like there’s always someone monitoring someone, Sev. If Rigel was to be believed someone was monitoring the planet. The question was who.
  Seconds turned to minutes, then hours. Hundreds of times, I considered looking into my restricted memories for information regarding the third-contact artifacts or the events in gamma-Ligata, and each time I found a reason not to. As Rigel had said, the chance of me getting off the planet alive was less than one percent, but the knowledge of the existence of the possibility kept me acting. And then there was Rigel’s offer…
  Rad, are you monitoring me? I asked, attempting to latch on to any open communication protocols. A connection was established, but instead of linking to Radiance, I found myself connecting back to Kridib’s mind. On cue, an info burst from Radiance followed, giving the latest scan. This time, I could see the location of our forces. The total number had increased to seventy-four, Kridib included. Nearly eight percent were gathered close to the captain’s expected location. Kridib and five more were closer to me.
  Get ready, Kridib said. Moments later, bursts of gunfire echoed in the distance; they were going for the captain first.
  The mission had begun. From here on, I could see several potential outcomes. In all of them, there was a high probability that Rigel attempted to make a deal.
  When I was a ship, Augustus had taught me one key thing when it came to missions: regardless of the depth of predictions and the computing power at their disposal, humans always boiled down a situation to a simple binary choice. Rigel wanted something from me and had invested too much to let his chance slip. Before the outcome of Kridib’s rescue mission, Rigel would come here to get an answer to his proposal. All I had to do was wait.
  As I lay, I watched Kridib run through the darkness towards my location. Unlike before, he was wearing night vision goggles, letting him make out his surroundings better.
  No thermal? I asked as Kridib made his way through the streets. The smell of burned vegetation could still be felt.
  That’s what you’re for.
  Not a reply to be thrilled about, but one to be expected. Cross-referencing Radiance’s latest scan, I started analysing every frame of Kridib’s stream. The first few minutes passed without incident. Judging by the intensified background gunfire, the locals were more focused on keeping Renaan isolated than stopping Kridib. Twenty-eight seconds, later the first shot sounded.
  Sniper! I shouted straight in Kridib’s mind.
  “Cover fire!” he shouted, rushing for cover.
  Watch out for a cross, I warned.
  The shooting intensified. Based on the area scan, the group was a few hundred meters away. One strong push and they’d be here. That said, I knew that the building was guarded by more than seven people. If I were in Rigel’s place, I would have dedicated at least three dozen.
  Concentrated fire focused on the second floor of a building, blowing off the entire wall. There was a brief scream before a rocket flew into the spot, hollowing the entire structure with a blast.
  Heavy weapons? I asked Kridib. I didn’t think Radiance’s captain would resort to such firepower, considering third-contact artifacts were involved; one direct hit, and the entire colony might well end up a smouldering crater, not to mention the potential communication repercussions. Maybe there was truth in Rigel’s statement that Flight Commander Nitel was getting desperate.
  As I was following Kridib’s advancement outside, the door opened once more—as predicted, Rigel had returned. He was wearing the same set of clothes as three hours ago. I found it puzzling that I couldn’t spot any semblance of a weapon on him.
  “Your masters have gotten desperate,” the man said in suspiciously calm fashion. “Looks like they’ve sent everything they had to get Renaan.” He walked up to me, then leaned over. “And just a handful to get you.”
  “Are they winning?” I tried to smile.
  “Beats me.” Rigel didn’t seem bothered. “You thought about my offer?”
  “I did. And I don’t think accepting would be a good deal. If I wait for them to rescue the captain, your bargaining power ends.”
  “Oh?” The man chuckled.
  “There’s nothing else the fleet would be willing to trade.” Except potentially the pyramid artifact. Even then, I didn’t see them sacrificing the Gregorius. “Once the captain boards a shuttle, it’s over.”
  A person of Kridib’s squad fell as they were approaching my building. I heard the unmistakable sound of bullets piercing armor, then silence. That was the thing about sound suppressors: one could get killed, and there still wouldn’t be any sound of one hitting the ground. I wanted to turn around and see what had happened, potentially to help. There was a seven-point-three chance that the wound wasn’t fatal. Kridib kept on moving forwards. That’s what made him a ground trooper… it also caused me pain.
  “What if I kill Renaan?” Rigel mused. “I won’t lose much. Everyone down here’s dead anyway. Someone in the fleet has gone through a lot of shit to get Renaan back. They’d lose a hell of a lot more.”
  “What if they save the captain?” I countered. “Either way, we’ll soon find out, and you’ll have no offer.”
  “Quantum paradox logic?” Rigel sounded surprised. “Strange hearing that from you, missy. I’ll have to skim your file once I’m out of here.” He paused for a moment, then dragged the nearby stool over—making a deliberate sound—and sat down. “Truth is, once the moment ends, we both lose our chance. Are you okay with that?”
  Why are you so confident? I wondered. Even if I were to agree, he wouldn’t be able to get much from me in the next ten minutes, even less if Kridib managed to reach my room. His squad had already made its way to the building proper, facing less than expected resistance. From what I was able to see, there were two snipers left on the upper floors and two machine-gunners on the first. All auxiliary positions on the nearby buildings seemed to have dealt with, although there was no sign of Ogum.
  “You’ve dealt with Salvage before, I can tell,” Rigel pressed on. “You won’t get another chance like this.”
  The old man’s with me in the basement, I told Kridib. No guards in the room. He’s ex-Salvage Authorities. Take him, and the mission is over. Saying that hurt slightly. Despite being the enemy, and a threat to the war effort, he remained human.
  “Then I guess I’ll never know.” As I spoke, I saw Kridib charge at the building. As before, there was nothing fancy about it, just determination and insanity. Several bullets flew so close to him I could hear them, but this time none of them hit. “Your bargaining window is over. No deal.”
  Kridib emptied his sidearm at the door in front of him, then rushed in. I could see no guards inside, just a set of hastily built staircases. Whatever the original purpose of the building was, it had been transformed into a field center at some point—likely during a previous escape attempt. Probably a group similar to ours had made it their temporary base, then left it as it was once they had completed their mission. No wonder Rigel had had me transported there. Kridib didn’t waste time making parallels, instead drawing his second sidearm and rushing down.
  At least two floors down, I said. I’m not hearing any of the gunfire.
  Is he armed? Kridib asked.
  Unsure. Not that I can tell. There are artifacts, though.
  “Such a teacher’s pet.” Rigel sighed after a long silence. “In the end, you’re nothing but a ship.” He stood up.
  He’s standing directly from the door, I said to Kridib. Seven degrees from center. Small frame, average height.
  Kridib fired three shots. Three bullets drilled through the alloy surface. Half a second later, Kridib followed kicking the door in.
  “Just one small thing.” Rigel took a tube-shaped object from his vest pocket.
  Meanwhile, I was staring at an empty room from Kridib’s eyes. It was at least three times smaller than the one I was in, bare and completely deserted. There was no Rigel, no me, no equipment, just a single metallic cube the size of my fingernail placed neatly on the floor.
  “Renaan was never the target.” The old man bent down and injected something in my neck. A new cascade of connection requests followed. “You are.”
—-
Next Chapter
submitted by LiseEclaire to HFY [link] [comments]

An interesting essay

Nail disorders are beyond cosmetic concern; besides discomfort in performance of daily chores, they disturb patients psychologically and affect their quality of life. Fungal nail infection (onychomycosis) is most prevalent nail related disorder affecting major population worldwide. Overcoming the impenetrable nail barrier is the toughest challenge for development of efficacious topical ungual formulation. Sophisticated techniques such as Iontophoresis, Photodynamic therapy have been proved to improve transungual permeation. This article provides updated and concise discussion regarding conventional approach and upcoming novel enhancers/research approaches focused to alter nail barrier. A comprehensive description regarding pre-formulation screening techniques for identification of potential ungual enhancers is described in this review. An attempt has been made to elaborately describe the characterization techniques for pre-screening of ungual enhancers and to highlight the current pitfalls for development of ungual delivery. 1. INTRODUCTION Skin and its auxiliary appendages such as hair and nails represent an area of great importance in dermatology or any cosmetic field because disorder in any of these parts have a direct impact on external appearance, psychological and normal daily routine. Nails disorders are not life threating but if untreated can transform from a non-specific to an exasperating problem, which consumes lot of time to restore into its normal condition. A synergistic combination of systemic with topical delivery is preferred approach for efficient treatment of onychomycosis. In spite of availability of several treatment options for ungual infection, none of the remedies give absolute fungal eradication. Psoriatic nail dystrophy is another common nail disorder, compared to skin psoriasis; treatment options for nail psoriasis are limited and often give disappointing result. Numerous strategies have been employed and succeeded to improve drug diffusion through the dense ungual keratin layers. A brief research based on novel approaches to treat ungual disorders has been described in this review. These agents have shown marked improved transungual diffusion of drug into the nail and compared to conventional ungual enhancers cause minimal damage to nail keratin. Major emphasis is given to biophysical and bioengineering techniques to utilize their potential to understand and characterize nail barrier for screening ungual enhancers. 1.1. The human nail and its anatomy A nail is a horn-like envelope covering the dorsal portion of the terminal phalanges of fingers and toes in humans, primates, and a few other mammals. Figure 1a. External nail antaomy Figure 1b. Layers of Nail plate The human nail apparatus comprises of nail plate, nail bed, nail folds, and the nail matrix. As shown in figure 1-the nail plate is the actual fingernail, consisting of translucent keratin covering the entire nail bed. The nail plate is a thick, elastic, convex structure composed of approximately 25 layers of tightly bound dead keratinised cells. The nail plate is divided into three layers, upper dorsal layer, intermediate layer followed by the inner ventral layer (figure 1b). The thickness of each layer is in the ratio 3:5:2 respectively [1].The dorsal layer is most resistant barrier for penetration of molecules.The cutaneous wedge shaped skin folds overlapping the sides and proximal end of the nail are the nail folds. The visible part of the nail matrix or the edge of the germinal matrix is called as lunula. It is white cresent moon shaped and is located at the base of nail (prominently visible on thumb nail) .The junction between the free edge and the skin of the fingertip is known as the hyponchium. It is an epithelium tissue and its function is to protect the nail bed. The seal between the nail plate and the hyponchium is known as the onchodermal band. A small band of epithelium extending between the posterior nail wall onto the base of the nail is known as the eponychium. The paronychium is the border tissue around the nail. It is also known as the paronychial edge and is the site of the infection of the nail disorder known as paronychia. [2] Figure 2. Internal nail anatomy Figure 2. Diagrammatically represents the interior structure of fingernail -The nail bed is the immediate living tissue present beneath the nail plate. The nail matrix (keratogenous membrane or onychostroma) is a living tissue located exactly below the lunula which protects the nail extending several millimetres into the finger. according to its Based on their function nail matrix is classified into subtypes namely sterile matrix and germinal matrix. The sterile matrix is responsible for the production of the nail bed. The germinal matrix produces the cells which subsequently become the nail plate. The edge of germinal matrix is visible, called as lunula of nail plate. The nail root (radix unguis) is the base of nail formed from the tissue growing below the matrix. The nail sinus (sinus unguis) is a deep furrow into which the nail root is inserted. [3] 1.2. Nail Disorders The two most frequent ungual disorders are onychomycosis and nail psoriasis. Onychomycosis is responsible for 50% of the nail disorders. It affects approximately 10% of the general population [4].It is more prevalent in diabetic and elderly population. Use of excessive immunosuppressant’s can also lead to onchomycosis. Nail psoriasis is reported in 80-90% of the patients suffering from skin psoriasis. It affects 1-3% of the total population [5]. A comprehensive description of nail disorders and their characteristics symptoms observed are listed briefly in table 1 Table 1. Nail disorders and their characteristics symptoms Disorder Characteristics observed Onychomycosis ‘ Fungal infection of nail plate caused by dermatophytes such as Trichophyton, epidermophyton and microsporum species(responsible for 80-90% of the cases), and seldom by non dermatophyte fungi such as Aspergillus, Fusarium spp, and yeasts such as Candida spp.[4] ‘ Fungii digests the nail keratin causing discolouration, thickening and splitting of nails. ‘ Irritation of the nails and pain is observed Nail Psoriasis ‘ Presence of scales pits on the nails, red and yellow discolouration of the nails. The skin under the nail gets thickened. ‘ Crumbling of nail is also observed. ‘ The nail plate gets separated from the nail bed.[6] Paronychia: ‘ Pain, redness and swelling of the nail fold and formation of pus filled blisters. ‘ The nail plate becomes thickened with prominent transverse ridges. Tinea unguis ‘ Thickening of the nails due to presence of ringworm infection. If left untreated can lead to complete loss of nail plate. Onychogryposis: ‘ Thickening of the nail plate and the nail plate is observed to curve inwards the nails, with a characteristics claw-type appearance [7]. Onychatrophia: ‘ Nail plate gets atrophised, loses its lustre, reduces in size and sometimes sheds entirely [7]. Koilonychia ‘ The nails become thin and concave in shape like a spoon and show raised ridges [7]. Melanonychia ‘ Black or brown pigmentation of the nail plate [8]. 1.3. Nail growth and regeneration The growth rate of normal fingernails varies from <1.8mm to '4.5mm per month [9]. The average growth of nail per day is 0.1mm. Toenails grow at a rate one-half to one-third of the growth of the fingernails. A normal fingernail generally grows fully in about 6 months whereas a toenail takes about 12 to 18 months for complete growth [10].In a dominant hand the nail growth is faster. The rate of nail growth is higher in males than females. Age and environment also play a major role for growth of nails. The rate of growth in nails is slow in the old age and high in cold climate. Environmental factors such as exposure to chemicals, strong detergents, reaction to adhesives used in artificial nails can lead to nail abnormalities. It is observed that after nail avulsion nails grow at faster rate [11]. Treatment with drugs such as benoxaprofen, biotin, cysteine, methionine, levodopa, itraconazole accelerates the nail growth. The nail growth is retarded in presence of infections and in conditions like fever, malnutrition, decreased circulation and lactation. Administration of antimycotic drugs also decreases the rate of nail growth [11]. 2. STRATEGIES TO ENHANCE TRANSUNGUAL PERMEATION OF DRUGS The nail keratin cells are tightly bound, arranged in form of compact blocks with no interstitial space in between. The thickness of the nail plate, its high sulphur content and the marked differences between the nail plate and the stratum corneum (Table 2) makes the nail plate an impenetrable barrier for transport of the drug across the nail plate. To overcome the tough nail barrier and enhance transungual drug delivery, several methods and techniques have been adapted by researchers, which are briefly described in this review. Table 2: Comparison between the nail plate and the stratum corneum [11]. Composition Nail Stratum corneum Thickness 500-1000??m 10-40??m Disulphide linkage 10.6% 1.2% % swelling in water 25% 200-300% Lipid content 0.1-1% 10-20% Table 3: Amino acid composition of the human nail plate and the stratum corneum [11]. Amino acid Stratum corneum Nail Lys 4.2% 3.1% S 1.4% 3.2% Glu 12.6% 13.6% Gly 24.5% 7.9% ?? Cys 1.2% 10.6% 2.1. Conventional approach Due to lack of basic understanding of nail anatomy and its permeability, initially mechanical methods such as partial removal of nail plate/complete nail avulsion followed by subsequent application of drug were used for treatment of onychomycosis [12, 13].These methods are non-patient compliant and are practically infeasible solution as a complete cure for onychomycosis. Disrupting basic nail keratin backbone, using disulphide reducing agents (sodium sulphite, dithioreitol) and keratolytic agents (urea, lactic acid, salicylic acid) are one of the common approaches for enhancing permeation of antifungals into the nails. Chemical agents such as urea, thioglycollic acid, and enzyme like papain interact with the disulphide bond of the nail keratin and facilitate their breakage, aiding improved transport of drug across the nail plate. [14] Recently sequential application of oxidising and reducing agents for improved transungual delivery was reported by M.D. brown et al. Two penetration enhancers (PEs), thioglycolic acid (TA) and urea hydrogen peroxide (urea H2O2) and their sequential pre-treatment onpermeation of three model permeants (caffeine, terbinafine and methyl paraben) were studied. The diffusion flux of all permeates were significantlyincreased in presence of the penetration enhancers. The sequential application of TA followed by urea H2O2 increased flux of terbinafine and caffeine but reversing their application order mild increase in flux of methyl paraben was observed [15]. 2.2. Sophisticated technologies Sophisticated technologies employing iontophoresis, ultrasound, and ultraviolet energy could alter nail keratin physically, with minimum damage, enhancing penetration of drug into the nail. a) Iontophoresis Iontophoresis is most effective technique for driving higher amount drug into the nail through the dense keratin layer [16, 17, 18, 19, 20]. With aid of iontophoresis drug depot can be formed into layers of nail keratin which gradually releases drug with time[21]. Hao and li examined the effect of iontophoresis on permeation of antifungal drug ciclopirox [21]. A small portable, disposable, user friendly device was developed which significantly delivered high amount of ciclopirox iontophoretically from its lacquer formulation compared to its passive delivery from same formulation and marketed lacquer penlac. Similar study was performed by Nair et al on human nail for enhancing delivery of terbinafinehcl [22]. Ionotophoresis could successfully drive ionic terbinafine molecules into the nail. Light microscopy study using methylene blue was performed and uptake of methylene blue was found to be highest using iontophoresis into the three layers of nail when compared with control. Manda et al studied iontophoretic delivery of terbinafine through proximal nail fold using cadaver toe nail model [23]. A custom designed polyurethane foam pad was employed as iontophoreic device which significantly delivered high amount of terbinafine into the nail matrix and deeper ungual layers compared to its passive delivery. b) Co2 lasers Lim et al used combination of fractional Co2 laser therapy with topical antifungal treatment for treating 24 patients suffering from onychomycosis [24]. Nail plate were punctured using ablative co2 laser followed by topical application of amolorofine cream. At the end of study, it was observed that the fungi resided area of the infected toenail of patients wassignificantly decreased with improved visual appearance. Out of 24, total of 22 patients (92%) showed a clinical response, and 12 patients (50%) showed a complete cure with a negative microscopic result and no adverse effect. The authors postulated that ablative fractional Co2 laser exerted direct fungicidal effect and created multiple porosities into nail plate enhancing the penetration of antifungal agent into the nail bed or matrix [24]. c) Etching/mesoscissing Etching involves production of minuscule micropores on surface of nail plate. Certain surface modifying agents such as phosphoric acid, tartaric acid, or devices such as (Path Former) creates microporosites on the nail surfaces, decreasing the contact angle providing a better surface for the drug to bind [25]. Path Former(Path Scientific, Carlisle, USA) is an FDA approved etching device, which creates miniature pin holes into the nails without affecting the nail bed and helps in draining the subungual hematomas [26]. The device uses electrical resistance of the nail as the feedback and eliminates the need for anaesthesia. The drilling of the nail plate is done by using a 400 micrometer tissue cutter and is retracted when it has penetrated into the nail plate. After the nail is etched a nail lacquer can be applied on the nails promoting sustained release of the drug. d) Ultrasound An ultrasound-mediated drug delivery system was developed by Abadi and Zderic, 2011 for treating onychomycosis. The slip-in device consists two compartments namely ultrasound transducers and drug delivery compartments above each toenail. The device is connected to a computer, where a software interface allows users to select their preferred course of treatment. Using an ultrasound-mediated drug delivery system, thrice amount of drug was delivered into the nail [27]. e) LaseUV Photodynamic therapy Laser wavelength in near infra- red region (780 nm -3000 nm) has capacity to directly heat the target tissues. Laser therapy has been reported in articles for curing onychomycosis [28, 29, 30, 31]. A pulsed laser technology has been employed for eradication of Trichophyton rubrum[30]. Direct thermal killing of fungal mycelia on nail clippings was observed when the temperature exceeded 50 degrees centigrade. Photodynamic therapies have shown remarkable results in treatment of skin related disorders [30, 31, 32]. Same technology was utilized Ryan et al, the authors treated infected fungal nail using a combination of a light sensitive drug (5-Aminolevulinic acid- ALA) and visible light which causes destruction of selected cells[33]. Incubation of dermatophytes such as Candida albicans and Trichophyton interdigitale in presence of ALA (10 mM), followed by irradiation with light caused reductions in viability of organisms by 87% and 42%, respectively. ALA was applied in form of bioadhesive patch on the human nails, ALA induced accumulation of photosensitizer called protoporphyrin IX which subsequently lead to photodynamic destruction of fungi. [33] 2.3. NOVEL UNGUAL PERMEATION ENHANCERS a. Water- Primary ungual permeation enhancer Water diffuses into the nail more rapidly compared to stratum corneum, also the rate of transonchial water loss from nail keratin is higher than tewl of stratum corneum [34, 35, 36]. Kelly et al compared the effect of plain organic and binary mixture of aqueous organic solvents systems on nail hydration and permeability [37].Ungual uptake and transport was correlated to concentration of organic solvent employed in study. It was observed that substituting water with a non-polar solvent decreases drug penetration across the nail plate. Higher the concentration of organic solvent, slower was ungual uptake and transport of radioactive probes across the nail. Water miscible solvents such as polyethylene/polypropylene glycol could hydrate the nail to higher extent compared to plain organic solvents. Nail keratin swells in presence of water and becomes more flexible. The hydrated keratin cells moves apart and the dense keratinized nail behaves like a hydrophilic gel matrix. Drug moieties can therefore diffuse through the hydrated keratin network with less resistance [38]. This principle was utilized by gunt et al to increase the permeation of ketoconazole through human nail. The permeability of antifungal ketoconazole was tested at different relative humidity (RH) to study effect of hydration on permeation of ketoconazole. Radiolabelled [3H] ketoconazole was employed to study the permeability of ketoconazole solution through human cadaver nails over a period of 40 days. The permeability of ketoconazole increased in order of three fold as the ambient RH was increased from 15 to 100%. [38]. Hui et al compared the penetration profile of ciclopirox between marketed organic solvent based lacquer (penlac), aqueous marketed gel and experimental gel [39]. The rate of permeation of ciclopirox in aqueous gel formulations were higher compared to penlac. Water itself acted as permeation enhancer which hydrated the nail and ultimately lead to an increased permeation of drug into nail. Similar results were obtained by D. Monti et al, permeation of two antifungal drugs ciclopirox and amolorfine in novel chitosan based water soluble nail lacquer were studied and compared with marketed amolorolfine lacquer (Loceryl) using bovine hoof slices [40]. The hydro soluble lacquers showed enhanced permeation and invitro antifungal activity into hoof keratin compared Loceryl. It was found that application of chitosan based ciclopirox nail lacquer on hoof keratin, resulted in rapid penetration of ciclopirox compared to marketed non aqueous lacquer. The growth of the fungus Candida parapsilosis was inhibited up to 30 hours after the application of hydrosoluble nail lacquer. The reason postulated by authors was presence of aqueous vehicle along with adhesion promoters like chitosan could lead effective transport of active across the nail keratin. [40] General conventional nail lacquers are based on water-insoluble resins and have limited potential to enhance the transungual drug delivery. On the contrary, aqueous-based lacquers can promote the nail hydration and drug diffusion across the nail plate, but suffer limitation of being easily wiped off or washed off the nail surface. Hence, to incorporate the properties of both water soluble and water insoluble nail lacquer Shivakumar et al. proposed a bilayered nail lacquer for onchomycosis treatment [41]. The lacquer consisted of two layers, underlying hydrophilic layer containing the drug terbinafine hydrochloride and an upper hydrophobic vinyl layer. The hydrophilic layer was based on HPMC and adhered well to the surface of the nails. The vinyl layer was applied to protect the underlying drug containing layer getting washed off during daily chores. It was found that the bilayered lacquer was resistant to drug loss on multiple washings and a significant high amount of terbinafinehcl was retain into nail layers compared to hydrophilic monolayer lacquer and control. In-vitro efficacy demonstrated an enhanced activity with bilayered lacquer. [41] b. SEPA: Hui et al used SEPA (2-n-Nonyl-1,3-dioxolane) for improving penetration of econazole from a nail lacquer formulation (Econail) [42]. It was found that addition of SEPA could increase permeation of econozole 6 times higher than control. Econail could deliver significantly higher amount of econozole in all three layers of nail and nail bed as compared to control. Dioxalones are generally skin permeation enhancers acting by altering lipid diffusion pathway of skin. The exact mechanism of dioxalone promoting econozole influx into the nail was not clearly understood but it was reported by author that SEPA acted as adhesion promoter and plasticizer for nail which facilitated increased diffusion of econozole into the nail. c. Hydrophobins: Hydrophobins are amphiphilic fungal proteins, which were recently proved by Vejnovic et al., 2010 as prospective transungual permeation enhancers [43].Vejnovic et al, investigated permeation enhancement potential of hydrophobins A-C for transport of terbinafinehcl across the nail. All the hydrophobins successfully increased permeability of terbinafine across the nail, hydrophobin B was superior among all of them showing highest permeability coefficient and 13 fold enhanced permeation of terbinafine. The mechanism of action by which hydrophobins act as permeation enhancers is still under research, some of their modes of action were reported by authors as follows. Structurally hydrophobins are stable having eight cysteine residues and four disulphide linkages, which lead to better protein interactions with keratin fibres and also with fungi proteins. Further, hydrophobins had amphipihilc structure with unique self- assembling and adherent properties and were able to coat terbinafine improving its solubility and physical stability. The coated terbinafine was found to have greater affinity for the hydrophilic gel membrane of the human nail thus increasing its permeation. Results suggested that the addition of hydrophobins improved permeability in the range of 3E'10 to 2E'9 cm/s. As of interest hydrophobins are new emerging ungual enhancers with unique features, more research is still required for investigating their complete potential as ungual enhancer and probably will be found. d. Keratolytic enzymes M. Mohorcic et al studied the effect of fungal keratinase produced by P. marquandiion on permeation characteristics of nail plate and bovine hoof [44]. It was found that the enzyme acted on the intercellular matrix which holds nail cells together, which resulted corneocytes separation from one another. SEM images showed that the corneocytes were 'lifted off' the plate and their surface was corroded. Pre-treatment of hoof with keratinase resulted in enhanced transungual permeation of model drug metformin. The permeability co-efficient and drug flux were found to be significantly increased in the presence of the enzyme. It was concluded that the enzyme, via its hydrolytic action on nail plate proteins can improve permeation and ungual uptake of drug. Similar Tiwary and Gupta isolated a combination of novel enzymes termed as Ker N which is chemically subtilisin-??-Glutamyl Transpeptidase from a feather degrading strain of Bacillus licheniformis [45]. The KerN enzyme increased the permeability of nail by loosening nail matrix and corroding the dorsal surface, which was confirmed by SEM images of nail plate treated with KerN. Drug permeation studies revealed that 58% clotrimazole was retained into the nail plates after 24 h exposure with 300 ??g/mL of kern in presence of drug. The enzyme had high potency and was found to be stable in presence of drug even after 72 h. The authors therefore proposed, KerN as a novel ungual enhancer to increase the permeability of drug during topical application on nail plates. e. Inorganic salts Inorganic salts such as sodium phosphate can serve as excellent, non-toxic, cheap ungual permeation enhancers [46]. Optimum concentrations of these salts have ability to increase the nail hydration with increased thermodynamic activity of drug. Nair et al studied effect of different inorganic salts (ammonium carbonate, sodium phosphate, calcium phosphate, potassium phosphate , sodium sulphite) on transungual permeation of terbinafineHCl. All the above salts enhanced transungual permeation of terbinafine in nail plate by 3 ' 5 folds. Among this, sodium phosphate showed highest, 5 fold enhancement of terbinafine permeation as compared to control. A 0.5 M sodium phosphate was employed as permeation enhancer in polaxamer based terbinafine gel and transungual in-vitro diffusion studies was carried using Franz diffusion cell. The cumulative amount of terbinafine permeated after 24 h from the formulated gel was higher than control. Hence, inorganic salts such as sodium phosphate can serve as promising novel ungual penetration enhancers f. Lipid diffusion enhancers Maibach et al incorporated ciclopirox in an oily vehicle consisting of benzyl alcohol, peppermint oil, turpentine and mineral oil, for enhanced transungual permeation. In contrast to hydrogel nature of nail, this lipophilic formulation showed significant rate of penetration of ciclopirox compared to its commercial lacquer penlac after 11 days in vitro diffusion study on human nail plate[47]. Ciclopirox content into all three layers of nail plate and nail bed from the novel lipidic formulation was found to be significantly higher than penlac. The authors hypothesized that though hydrophilic pathway is predominant pathway for molecules to diffuse into the nail, there exist miniature lipidic pathway into the nail through which lipophilic moieties traverses and by passes the impenetrable keratin corneocytes. This new pathway can be studied and further explored to develop more efficacious ungual formulations. Thus an appropriate combination of hydrophilic and lipophilic enhancers is suspected to give optimum and efficacious drug delivery into ungual layers.
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Cryptosoft Review 2020-Is it a Scam?

Cryptosoft Review 2020-Is it a Scam?

Most f the reviews we tend to have come back across reveal that the Cryptp soft platform is easy to
Their client service is very efficient. We did a live check and confirmed that they respond at intervals a moment. Moreover, they are available 24/7.
The Cryptp soft app is secure. They need all the mandatory measures in place to make sure data privacy.
The Cryptp soft System is considered by several among the most effective robots within the market nowadays. We have a tendency to realize this robot to perform virtually the same with Bitcoin Rush, another top bitcoin robot. Read the review of Bitcoin Rush for more data?
Cryptp soft registration method is straightforward, easy, and secure. You only want but 10 minutes to form an account and begin trading. Cryptp soft is a absolutely auto bot and is so accessible to everyone.

https://preview.redd.it/giu6kclgfnn51.jpg?width=1280&format=pjpg&auto=webp&s=f605d84ba2174f831ca825dbaffddf061b3a55b5
You do not want to perceive trading lingo to use Immediate Edge. The following steps can get you started with this robot.
STEP ONE: Fill the Signup type

Visit the Cryptp soft home page and register your name, phone number, and email in the provided kind. You will be asked to verify your phone variety via a text code and email through a link. CryptoVibes will ascertain that the Cryptp soft registration process is secure.

Their web site is SSL secured to confirm that hackers cannot steal personal information submitted through it. Cryptp soft cyber safety policy states that they're GDPR adherent. This suggests that they handle your knowledge with strict privacy.
STEP TWO: Get matched with a broker

The Cryptp soft Software then matches you with one in every of their partner brokers. The role of the broker is to receive deposits and facilitate transactions. We have a tendency to have determined that Cryptp soft only partners with regulated brokers.

With a regulated broker, they guarantee that your cash is safe. Reputable regulators such as the FCA, FSB, ASIC, and CySEC need brokers to segregate deposits and submit periodic reports on deposit usage.
You wold like a deposit of a minimum of $250 to trade with Immediate Edge. Do not confuse this quantity with the value of the robot. Cryptp soft does not need any license fee. The house owners of this robot build money by charging a small commission on the profits generated through the app
Deposits with Cryptp soft should be created through Wire Transfer, Visa, and MasterCard. It takes a few seconds for a deposit to reflect in an exceedingly trader’s account. Cryptp soft does not charge any deposit fees.
The Cryptp soft does provide a demo account to help traders familiarize themselves with its web-trader. CryptoVibes recommends that you are doing demo trading before going to live to trade. Please note that the demo is for demonstrative purposes solely.
The results you receive on the platform are primarily based on historical information and could therefore not mirror what you'll get in live trading.
The Cryptp soft live trader comes with features to help you outline the amount of risk you are willing to require per trade. You wish to go through the demo account to familiarize with these features. As mentioned severally in this review, you do not want specialized skills to use this robot.
Live trading with Cryptp soft involves determining the quantity of capital you plan to risk per trade and clicking the live button. Scan our review of Bitcoin Trader for one more straightforward to use the robot.
*Remember all trading risks and you shouldn’t risk more then you'll be able to afford to lose.
How to get the most out of Cryptp soft App
We have identified the following tips as paramount in guaranteeing that you make the most of Immediate Edge.
Begin with a deposit of $250 – Given the level of risk involved in trading with Immediate Edge, you should start with a tiny investment.
Follow crypto market news – You need to determine the type of reports that drives volatility high and capitalize on them. Cryptp soft claims to form the foremost profits throughout high market volatility.
Trade for eight hours per day – In keeping with Immediate Edge, trading for at least eight hours per day can help maximize profits. Cryptp soft is entirely auto, and hence you'll be able to leave the robot running as you continue together with your daily errands. You are doing not want more than twenty minutes per day to observe your account.
Close trading sessions at the tip of the day – Leaving open positions overnight is doubtless to translate to losses since the markets can change considerably overnight. It is better to shut sessions even if in the negative and start trading again the subsequent day. With a correct risk management strategy, there is no would like to fret concerning periodic losses.
Following our review we tend to realize Cryptp soft to be legit. But, traders ought to take additional caution, provided that this bot comes at a degree of risk. Whereas the app claims it's potential to form profits of up to 50percent per day, you'll be able to additionally lose the complete deposit inside seconds. This is often not sudden for a high-frequency trading robot.
We recommend that you just apply the required risk management measures. As a rule of thumb don't risk more than 10percent of your trading capital per trade. Also, never trade with an amount you cannot afford to lose. It is prudent to start small and add cash as you get conversant with the various features on the platform.
Recently, a brand new trading software was added to the bitcoin investment trade. This software is termed Cryptp soft and it is allegedly created by a corporation or organization called the International Council for Bitcoin.
There is additionally a letter out there on their web site that has been signed by someone named David. This person claims to own earned over 1,000,000 as a results of investing in bitcoins. What’s very shocking concerning this letter is that David claims to have earned that huge quantity in just one trade. If we have a tendency to place it in simple words, David became a millionaire overnight.
We tend to highly doubt that a trading system that has been launched recently will have such potential. To verify the main points of this software and to determine its legitimacy, we have a tendency to conducted our own research and investigation.
Cryptp soft is a bitcoin trading software that’s meant to assist newbie traders get involved in Cryptocurrency trading with less risk than ancient investment opportunities. Cryptp soft software was created by The International Council For Bitcoin who is PRO Bitcoin trader Group behind the Cryptp soft software. Notice out all concerning Cryptp soft software by The International Council For Bitcoin.
Cryptp soft Software may be a nice development by a famous, well established and experienced bitcoin trader Investors with a viewpoint to enable traders to perform different tasks with ease and convenience.

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Cryptp soft Software is essentially a Binary choices trading software that is designed to assist traders win and predict the Binary options trend of their respective choices. Cryptp soft APP works as a code to urge financial success, shows traders how they'll make money on-line, helps them to find different ways in which to induce huge returns on their investment. The Cryptp soft Trading Software additionally provides analyses of Market conditions so that traders will recognize what ought to be their next step. Cryptp soft System gives secret cryptocurrency ways that ultimately help binary traders to create thousands of greenbacks solely for some bucks.
Several individuals can say that Cryptocurrency Trading may be a risky business and tend to remain faraway from it. But from my expertise, high volatility means HIGH RETURN OF INVESTMENT in Crypto Market. But this can be where the Cryptp soft comes into play, the mathematical algorithm used by Cryptp soft Software takes the guesswork out choosing a winning profitable trade. You don’t must be an expert. Like I said earlier, I actually have personally tested the Cryptp soft and found the success rate is about ninety sevenpercent. I don’t apprehend concerning you, but a ninety seven% probability of earning a profitable trade is TERRIBLY GOOD! I’ve never come across something like this trading software before. Keep reading, below are my Cryptp soft results for the past week or so…
Watch over the Shoulder of a Professional Each Day and you'll be able to learn as you trade.
Averaging 97% Winning Weeks With Cryptp soft which suggests that more potential profits for you
Cryptp soft Software Are Fully Transparent
No previous experience with binary choices trading required
Web-based mostly, no need for downloads, additionally works on phones, tablets
You'll be able to Even Watch Cryptp soft Signals From Your Phone (iPhone Users — Photon Browser)
If you are ready to begin making cash online with an on the spot edge, there has never been a better chance than currently. If you enjoy surfing the web for countless hours trying for the next Trading Method Secrets, never being able to urge centered, being overloaded with conflicting information, and not creating cash on-line, you ought to probably leave this page right now and get back to that Cryptp soft System strategy
Cryptp soft bot could be a new cryptocurrency trading invention that comes with options that create this software stand out among others. It is conjointly an automatic trading platform that uses a smart program algorithm to detect favorable trading opportunities. It acts on its own or waits for a prompt command from the user depending on the software’s settings. But what makes this software unique and a favorite to individuals is what we have a tendency to shall unveil in this review.
There have been lots of unverified claims of how totally different cryptocurrency software have helped several people to make massive profits leading to Scam individuals. However, it's pertinent for cryptocurrency traders to verify if a particular trading software may be a scam or legit, which is also ?
After subjecting the features of the Cryptp soft bot software to a series of tests, the software isn't a scam however legit. The Cryptp soft bot is believed to have successful rate of 85%, that is a lot of than the 80percent benchmark for average software. The Cryptp soft bot has helped cryptocurrency traders to make sensible profits, which has been documented as testimonies on the software’s website.
Trading on the platform is straightforward and might not require experience. We had to verify the simplicity of the software, and we tend to discovered that the software is easy to navigate. The demo trading feature of the software makes it potential for brand new users to hold out trading activities in an exceedingly simulated atmosphere while not having to risk their investment. This any gives credence to the legitimacy of the software because it ensures that new users get accustomed to the features of the software before continuing to measure to trade
As earlier stated, the Cryptp soft bot could be a high-tech program software that comes with exceptional options that makes it among the simplest cryptocurrency trading software in the blockchain market. The outstanding features of the Cryptp soft bot embody the subsequent:
https://www.cryptoerapro.com/cryptosoft/

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https://twitter.com/cryptoerapro

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